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Lexapro Generic Name & Formulations
Legal Class
General Description
Pharmacological Class
See Also
How Supplied
Manufacturer
Mechanism of Action
Lexapro Indications
Indications
Lexapro Dosage and Administration
Adult
Initially 10mg once daily; may increase to max 20mg once daily at an interval of no less than 1 week. Elderly or hepatic impairment: 10mg once daily.
Children
<7yrs: not established. Initially 10mg once daily; may increase to max 20mg once daily at an interval of no less than 2 weeks. Hepatic impairment: 10mg once daily.
Lexapro Contraindications
Contraindications
Lexapro Boxed Warnings
Boxed Warning
Lexapro Warnings/Precautions
Warnings/Precautions
Increased risk of suicidal thinking and behavior in children, adolescents, and young adults; monitor for clinical worsening and unusual changes. History of seizures or mania/hypomania. Monitor for serotonin syndrome; discontinue if occurs. Hepatic impairment: see Adult and Children Dosage. Renal impairment (CrCl <20mL/min): not studied. Angle-closure glaucoma. Conditions that affect metabolic or hemodynamic responses. Recent MI. Unstable heart disease. Volume-depleted. Hyponatremia (esp. elderly). Sexual dysfunction. Avoid abrupt cessation. Reevaluate periodically. Write ℞ for smallest practical amount. Elderly. Labor & delivery. Pregnancy (during 3rd trimester; see full labeling for effects on neonate). Nursing mothers: monitor.
Lexapro Pharmacokinetics
Absorption
Absolute bioavailability: ~80%.
Peak blood levels occur at ~5 hours.
Distribution
Volume of distribution: ~12 L/kg.
Plasma protein bound: ~56%.
Elimination
Half-life: ~27–32 hours.
Oral clearance: 600 mL/min.
Lexapro Interactions
Interactions
See Contraindications. Do not give with citalopram. Increased risk of serotonin syndrome with other serotonergic drugs (eg, SSRIs, SNRIs, triptans, tricyclic antidepressants, fentanyl, lithium, tramadol, meperidine, methadone, tryptophan, buspirone, amphetamines, St. John's Wort) or with drugs that impair serotonin metabolism (eg, MAOIs, linezolid, IV methylene blue). Avoid alcohol. Increased risk of bleeding with concomitant NSAIDs, aspirin, warfarin, and others that affect coagulation. May be antagonized by carbamazepine. Caution with drugs metabolized by CYP2D6 or other centrally-acting drugs. Increases metoprolol levels.
Lexapro Adverse Reactions
Adverse Reactions
Lexapro Clinical Trials
See Literature
Lexapro Note
Not Applicable
Lexapro Patient Counseling
See Literature
Lexapro Generic Name & Formulations
Legal Class
General Description
Pharmacological Class
See Also
How Supplied
Manufacturer
Mechanism of Action
Lexapro Indications
Indications
Major depressive disorder (MDD).
Lexapro Dosage and Administration
Adult
Initially 10mg once daily; may increase to max 20mg once daily at an interval of no less than 1 week. Elderly or hepatic impairment: 10mg once daily.
Children
Lexapro Contraindications
Contraindications
Lexapro Boxed Warnings
Boxed Warning
Lexapro Warnings/Precautions
Warnings/Precautions
Increased risk of suicidal thinking and behavior in children, adolescents, and young adults; monitor for clinical worsening and unusual changes. History of seizures or mania/hypomania. Monitor for serotonin syndrome; discontinue if occurs. Hepatic impairment: see Adult and Children Dosage. Renal impairment (CrCl <20mL/min): not studied. Angle-closure glaucoma. Conditions that affect metabolic or hemodynamic responses. Recent MI. Unstable heart disease. Volume-depleted. Hyponatremia (esp. elderly). Sexual dysfunction. Avoid abrupt cessation. Reevaluate periodically. Write ℞ for smallest practical amount. Elderly. Labor & delivery. Pregnancy (during 3rd trimester; see full labeling for effects on neonate). Nursing mothers: monitor.
Lexapro Pharmacokinetics
Absorption
Absolute bioavailability: ~80%.
Peak blood levels occur at ~5 hours.
Distribution
Volume of distribution: ~12 L/kg.
Plasma protein bound: ~56%.
Elimination
Half-life: ~27–32 hours.
Oral clearance: 600 mL/min.
Lexapro Interactions
Interactions
See Contraindications. Do not give with citalopram. Increased risk of serotonin syndrome with other serotonergic drugs (eg, SSRIs, SNRIs, triptans, tricyclic antidepressants, fentanyl, lithium, tramadol, meperidine, methadone, tryptophan, buspirone, amphetamines, St. John's Wort) or with drugs that impair serotonin metabolism (eg, MAOIs, linezolid, IV methylene blue). Avoid alcohol. Increased risk of bleeding with concomitant NSAIDs, aspirin, warfarin, and others that affect coagulation. May be antagonized by carbamazepine. Caution with drugs metabolized by CYP2D6 or other centrally-acting drugs. Increases metoprolol levels.
Lexapro Adverse Reactions
Adverse Reactions
Lexapro Clinical Trials
See Literature
Lexapro Note
Not Applicable
Lexapro Patient Counseling
See Literature
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