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Intuniv Generic Name & Formulations
Legal Class
Rx
General Description
Guanfacine (as HCl) 1mg, 2mg, 3mg, 4mg; ext-rel tabs.
Pharmacological Class
Central alpha-2A agonist.
How Supplied
Tabs—100
Manufacturer
Generic Availability
YES
Intuniv Indications
Indications
Attention deficit hyperactivity disorder (ADHD), as monotherapy or as an adjunct to stimulant medications.
Intuniv Dosage and Administration
Adult
≥18yrs: not established.
Children
Swallow whole with water, milk, or other liquid. Do not give with high-fat meals. <6yrs: not established. 6–17yrs: Initially 1mg once daily; adjust in increments of no more than 1mg/week; target range: 0.05–0.12mg/kg/day (1–7mg/day). Doses >4mg/day: not evaluated in children (6–12yrs); doses >7mg/day: not evaluated in adolescents (13–17yrs). Reevaluate periodically. Withdraw gradually (by 1mg every 3–7 days). Dose adjustment with concomitant strong and moderate CYP3A4 inhibitors or inducers: see full labeling.
Intuniv Contraindications
Contraindications
Concomitant use with other forms of guanfacine.
Intuniv Boxed Warnings
Not Applicable
Intuniv Warnings/Precautions
Warnings/Precautions
Do not substitute with other forms of guanfacine on a mg-mg basis. Concomitant antihypertensives, other risks for hypotension, syncope, bradycardia, heart block, cardiovascular or cerebrovascular disease. Monitor heart rate and BP prior to initiation, after dose increases, and periodically during therapy. Dehydration. Elevated temperature. Cardiac conduction abnormalities. Avoid abrupt discontinuation to minimize risk of rebound hypertension. Renal or hepatic impairment. Pregnancy. Nursing mothers: monitor infants.
Intuniv Pharmacokinetics
See Literature
Intuniv Interactions
Interactions
Avoid with alcohol. May be potentiated by strong and moderate CYP3A4 inhibitors (eg, ketoconazole, fluconazole). May be antagonized by strong and moderate CYP3A4 inducers (eg, carbamazepine, rifampin, efavirenz). Additive effects with other antihypertensives, CNS depressants (eg, benzodiazepines, antipsychotics, barbiturates). May worsen sinus node dysfunction and AV block when concomitant other sympatholytic drugs; monitor.
Intuniv Adverse Reactions
Adverse Reactions
Somnolence, sedation, fatigue, nausea, lethargy, hypotension, insomnia, dizziness, abdominal pain, dry mouth, vomiting, irritability, constipation; bradycardia, hypertensive encephalopathy.
Intuniv Clinical Trials
See Literature
Intuniv Note
Not Applicable
Intuniv Patient Counseling
See Literature
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