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Haloperidol Tablets Generic Name & Formulations
Legal Class
Rx
General Description
Haloperidol 0.5mg, 1mg, 2mg, 5mg, 10mg, 20mg; scored tabs.
Pharmacological Class
Butyrophenone.
How Supplied
Contact supplier.
Manufacturer
Haloperidol Tablets Indications
Indications
Psychosis. Tourette's disorder. For severe behavior disorders or as a short-term treatment for hyperactivity in children who are refractory to psychotherapy or other medications.
Haloperidol Tablets Dosage and Administration
Adult
Individualize. Initially: Moderate symptoms: 0.5mg–2mg 2–3 times daily. Severe, chronic, or resistant symptoms: 3mg–5mg 2–3 times daily. Debilitated: 0.5mg–2mg 2–3 times daily. Max: 100mg/day.
Children
<3yrs: not recommended. Total dose may be divided, to be given 2–3 times daily. ≥3yrs: initially 0.5mg daily, may increase at increments of 0.5mg at 5–7 day intervals. Psychosis: 0.05mg/kg/day–0.15mg/kg/day. Nonpsychotic behavior and Tourette's: 0.05mg/kg/day–0.075mg/kg/day. Max 6mg/day.
Haloperidol Tablets Contraindications
Contraindications
Severe CNS depression. Coma. Parkinsonism.
Haloperidol Tablets Boxed Warnings
Boxed Warning
Increased mortality in elderly patients with dementia-related psychosis.
Haloperidol Tablets Warnings/Precautions
Warnings/Precautions
Elderly with dementia-related psychosis (not approved use): increased risk of death. Risk of QT prolongation: electrolyte disturbances (eg, hypokalemia, hypomagnesemia), underlying cardiac abnormalities, hypothyroidism, familial long QT-syndrome, concomitant drugs known to prolong the QT interval. Seizures. Thyrotoxicosis. Pre-existing low WBCs or history of leukopenia/neutropenia; monitor CBCs during 1st few months of treatment; discontinue if WBCs decline. Severe cardiovascular disorders. Mania. Avoid abrupt cessation. Debilitated. Neonates: risk of extrapyramidal and/or withdrawal symptoms post delivery (due to exposure during 3rd-trimester pregnancy). Pregnancy. Nursing mothers: not recommended.
Haloperidol Tablets Pharmacokinetics
See Literature
Haloperidol Tablets Interactions
Interactions
CNS depression potentiated with alcohol, other CNS depressants. Possible neurotoxicity with lithium: monitor, discontinue if occurs. Caution with drugs that prolong the QT interval (eg, ketoconazole, paroxetine). May be potentiated by CYP3A4 inhibitors/substrates or CYP2D6 enzymes (eg, itraconazole, nefazodone, buspirone, venlafaxine, alprazolam, fluvoxamine, quinidine, fluoxetine, sertraline, chlorpromazine, promethazine. May be antagonized by CYP3A4 inducers (eg, rifampin, carbamazepine); monitor and adjust doses. May increase intraocular pressure with anticholinergics. Monitor anticoagulants.
Haloperidol Tablets Adverse Reactions
Adverse Reactions
Tardive dyskinesia, extrapyramidal symptoms, CNS effects, GI upset, cardiovascular effects, bronchopneumonia, neuroleptic malignant syndrome.
Haloperidol Tablets Clinical Trials
See Literature
Haloperidol Tablets Note
Notes
Formerly known under the brand name Haldol.
Haloperidol Tablets Patient Counseling
See Literature
