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Halcion Generic Name & Formulations
Legal Class
CIV
General Description
Triazolam 0.25mg; scored tabs.
Pharmacological Class
Benzodiazepine.
How Supplied
Tabs—10, 100
Manufacturer
Generic Availability
YES
Halcion Indications
Indications
Short-term (7–10 days) treatment of insomnia.
Halcion Dosage and Administration
Adult
Use lowest effective dose. 0.125–0.25mg at bedtime; max 0.5mg. Elderly: initially 0.125mg; max 0.25mg. Reevaluate if used ≥3 weeks. Max 1 month/℞.
Children
Not established.
Halcion Contraindications
Contraindications
Concomitant strong CYP3A inhibitors (eg, ketoconazole, itraconazole, clarithromycin, nefazodone, ritonavir, indinavir, nelfinavir, saquinavir, lopinavir, grapefruit juice).
Halcion Boxed Warnings
Boxed Warning
Risks from concomitant use with opioids. Abuse, misuse, and addiction. Dependence and withdrawal reactions.
Halcion Warnings/Precautions
Warnings/Precautions
Increased risk of drug-related mortality from concomitant use with opioids. Evaluate for co-morbid diagnoses (eg, physical and/or psychiatric disorders) prior to treatment. Reevaluate if insomnia fails to remit after 7–10 days of use. Depression. Suicidal tendencies. Evaluate any new onset of behavioral changes. Compromised respiratory function (monitor); consider discontinuing if respiratory depression or apnea occurs. Assess patient's risk for abuse, misuse, addiction prior to and during therapy. Avoid abrupt cessation. Withdraw gradually. Drug or alcohol abusers. Elderly (higher risk of falls). Neonates. Pregnancy. Nursing mothers: monitor infants (consider interrupting breastfeeding or pumping/discarding breast milk during and for 28hrs after dose).
Halcion Pharmacokinetics
See Literature
Halcion Interactions
Interactions
See Contraindications. Increased sedation, respiratory depression, coma, and death with concomitant opioids; reserve use in those for whom alternative treatment options are inadequate; if needed, limit dosages/durations to minimum and monitor. Additive CNS depressant effects with alcohol or other CNS depressants (eg, other benzodiazepines, psychotropics, anticonvulsants, antihistamines); consider dose reductions. Potentiated by moderate/weak CYP3A inhibitors (eg, erythromycin, cimetidine, isoniazid, oral contraceptives, ranitidine); consider reducing triazolam dose. Caution with fluvoxamine, diltiazem, verapamil, sertraline, paroxetine, ergotamine, cyclosporine, amiodarone, nicardipine, nifedipine.
Halcion Adverse Reactions
Adverse Reactions
Drowsiness, headache, dizziness, nervousness, light-headedness, ataxia, nausea, vomiting; worsening of insomnia, complex behaviors (eg, sleep-driving), daytime anxiety (discontinue if worsens), anterograde amnesia, paradoxical reactions, withdrawal reactions.
Halcion Clinical Trials
See Literature
Halcion Note
Not Applicable
Halcion Patient Counseling
See Literature
