Geodon For Injection Generic Name & Formulations
Legal Class
Rx
General Description
Ziprasidone (as mesylate) 20mg/mL; pwd for IM inj after reconstitution; preservative-free.
Pharmacological Class
Serotonin and dopamine antagonist.
See Also
How Supplied
Caps—60; Single-use vials—10
Manufacturer
Generic Availability
YES
Geodon For Injection Indications
Indications
Rapid control of acute agitation.
Geodon For Injection Dosage and Administration
Adult
10–20mg IM as needed, max 40mg/day (10mg every 2hrs; or 20mg every 4hrs); usual max 3 days. Switch to oral form as soon as possible.
Children
Not established.
Geodon For Injection Contraindications
Contraindications
History of QT prolongation. Congenital long QT syndrome. Recent acute MI. Uncompensated heart failure. Concomitant drugs that cause QT prolongation, including dofetilide, sotalol, quinidine, other Class Ia and III antiarrhythmics, mesoridazine, thioridazine, chlorpromazine, droperidol, pimozide, sparfloxacin, gatifloxacin, moxifloxacin, halofantrine, mefloquine, pentamidine, arsenic trioxide, levomethadyl, dolasetron, probucol, tacrolimus.
Geodon For Injection Boxed Warnings
Boxed Warning
Increased mortality in elderly patients with dementia-related psychosis.
Geodon For Injection Warnings/Precautions
Warnings/Precautions
Increased mortality in elderly with dementia-related psychosis (not approved use). Concomitant use of oral and IM forms: not recommended. Renal (IM form) or hepatic impairment (both forms). Discontinue if QTc >500 msec persists, neuroleptic malignant syndrome, unexplained rash occurs, or if severe skin reactions (eg, Stevens-Johnson syndrome or DRESS) are suspected; consider discontinuing if tardive dyskinesia occurs. Conditions that increase risk of torsade de pointes (eg, bradycardia, hypokalemia, hypomagnesemia). Monitor potassium, magnesium, others if risk of electrolyte disturbances (eg, diarrhea); correct imbalance before starting. Avoid in significant cardiovascular disease (eg, arrhythmias). Evaluate cardiac function if symptoms of torsade de pointes occur (eg, dizziness, palpitations, syncope). Cardio- or cerebrovascular disease. Pre-existing low WBCs or history of leukopenia/neutropenia; monitor CBCs during 1st few months of treatment; discontinue if WBCs decline. Diabetes; monitor for hyperglycemia. Monitor weight. Risk of hypotension or seizures. History of breast cancer. Dysphagia. Exposure to extreme heat. Perform fall risk assessments when initiating and recurrently on long-term therapy. Reevaluate periodically. Write ℞ for smallest practical amount. Neonates: risk of extrapyramidal and/or withdrawal symptoms post delivery (due to exposure during 3rd-trimester pregnancy). Pregnancy. Nursing mothers: monitor infants.
Geodon For Injection Pharmacokinetics
See Literature
Geodon For Injection Interactions
Interactions
See Contraindications. May potentiate CNS drugs, antihypertensives. May antagonize levodopa, dopamine agonists. Extent of absorption and/or plasma levels may be affected by CYP3A4 inducers (eg, carbamazepine) or inhibitors (eg, ketoconazole). Correct hypokalemia, hypomagnesemia due to diuretics.
Geodon For Injection Adverse Reactions
Adverse Reactions
Somnolence, extrapyramidal syndrome, respiratory disorder, dizziness, akathisia, abnormal vision, asthenia, vomiting, nausea, rash, dystonia, postural hypotension, QTc prolongation, headache, weight gain, inj site reactions, hyperprolactinemia, dyslipidemia, hyperglycemia; rare: priapism, leukopenia, neutropenia, agranulocytosis (may be fatal).
Geodon For Injection Clinical Trials
See Literature
Geodon For Injection Note
Not Applicable
Geodon For Injection Patient Counseling
See Literature