Geodon Generic Name & Formulations
Legal Class
Rx
General Description
Ziprasidone (as HCl) 20mg, 40mg, 60mg, 80mg; caps.
Pharmacological Class
Serotonin and dopamine antagonist.
See Also
How Supplied
Caps—60
Manufacturer
Generic Availability
YES
Geodon Indications
Indications
Acute treatment of manic or mixed episodes in bipolar disorder as monotherapy; or as an adjunct to lithium or valproate for maintenance treatment.
Geodon Dosage and Administration
Adult
Swallow whole. Take with food. Initially 40mg twice daily; may increase on day 2 to 60mg or 80mg twice daily; usual range 40–80mg twice daily. Elderly: consider lower initial dose, slower titration.
Children
Not established.
Geodon Contraindications
Contraindications
History of QT prolongation. Congenital long QT syndrome. Recent acute MI. Uncompensated heart failure. Concomitant drugs that cause QT prolongation, including dofetilide, sotalol, quinidine, other Class Ia and III antiarrhythmics, mesoridazine, thioridazine, chlorpromazine, droperidol, pimozide, sparfloxacin, gatifloxacin, moxifloxacin, halofantrine, mefloquine, pentamidine, arsenic trioxide, levomethadyl, dolasetron, probucol, tacrolimus.
Geodon Boxed Warnings
Boxed Warning
Increased mortality in elderly patients with dementia-related psychosis.
Geodon Warnings/Precautions
Warnings/Precautions
Increased mortality in elderly with dementia-related psychosis (not approved use). Concomitant use of oral and IM forms: not recommended. Renal (IM form) or hepatic impairment (both forms). Discontinue if QTc >500 msec persists, neuroleptic malignant syndrome, unexplained rash occurs, or if severe skin reactions (eg, Stevens-Johnson syndrome or DRESS) are suspected; consider discontinuing if tardive dyskinesia occurs. Conditions that increase risk of torsade de pointes (eg, bradycardia, hypokalemia, hypomagnesemia). Monitor potassium, magnesium, others if risk of electrolyte disturbances (eg, diarrhea); correct imbalance before starting. Avoid in significant cardiovascular disease (eg, arrhythmias). Evaluate cardiac function if symptoms of torsade de pointes occur (eg, dizziness, palpitations, syncope). Cardio- or cerebrovascular disease. Pre-existing low WBCs or history of leukopenia/neutropenia; monitor CBCs during 1st few months of treatment; discontinue if WBCs decline. Diabetes; monitor for hyperglycemia. Monitor weight. Risk of hypotension or seizures. History of breast cancer. Dysphagia. Exposure to extreme heat. Perform fall risk assessments when initiating and recurrently on long-term therapy. Reevaluate periodically. Write ℞ for smallest practical amount. Neonates: risk of extrapyramidal and/or withdrawal symptoms post delivery (due to exposure during 3rd-trimester pregnancy). Pregnancy. Nursing mothers: monitor infants.
Geodon Pharmacokinetics
See Literature
Geodon Interactions
Interactions
See Contraindications. May potentiate CNS drugs, antihypertensives. May antagonize levodopa, dopamine agonists. Extent of absorption and/or plasma levels may be affected by CYP3A4 inducers (eg, carbamazepine) or inhibitors (eg, ketoconazole). Correct hypokalemia, hypomagnesemia due to diuretics.
Geodon Adverse Reactions
Adverse Reactions
Somnolence, extrapyramidal syndrome, respiratory disorder, dizziness, akathisia, abnormal vision, asthenia, vomiting, nausea, rash, dystonia, postural hypotension, QTc prolongation, headache, weight gain, hyperprolactinemia, dyslipidemia, hyperglycemia; rare: priapism, leukopenia, neutropenia, agranulocytosis (may be fatal).
Geodon Clinical Trials
See Literature
Geodon Note
Not Applicable
Geodon Patient Counseling
See Literature
Geodon Generic Name & Formulations
Legal Class
Rx
General Description
Ziprasidone (as HCl) 20mg, 40mg, 60mg, 80mg; caps.
Pharmacological Class
Serotonin and dopamine antagonist.
See Also
How Supplied
Caps—60; Single-use vials—10
Manufacturer
Generic Availability
YES
Geodon Indications
Indications
Schizophrenia.
Geodon Dosage and Administration
Adult
Swallow whole. Take with food. Initially 20mg twice daily; may increase at intervals of at least 2 days; max 80mg twice daily. Elderly: consider lower initial dose, slower titration.
Children
Not established.
Geodon Contraindications
Contraindications
History of QT prolongation. Congenital long QT syndrome. Recent acute MI. Uncompensated heart failure. Concomitant drugs that cause QT prolongation, including dofetilide, sotalol, quinidine, other Class Ia and III antiarrhythmics, mesoridazine, thioridazine, chlorpromazine, droperidol, pimozide, sparfloxacin, gatifloxacin, moxifloxacin, halofantrine, mefloquine, pentamidine, arsenic trioxide, levomethadyl, dolasetron, probucol, tacrolimus.
Geodon Boxed Warnings
Boxed Warning
Increased mortality in elderly patients with dementia-related psychosis.
Geodon Warnings/Precautions
Warnings/Precautions
Increased mortality in elderly with dementia-related psychosis (not approved use). Concomitant use of oral and IM forms: not recommended. Renal (IM form) or hepatic impairment (both forms). Discontinue if QTc >500 msec persists, neuroleptic malignant syndrome, unexplained rash occurs, or if severe skin reactions (eg, Stevens-Johnson syndrome or DRESS) are suspected; consider discontinuing if tardive dyskinesia occurs. Conditions that increase risk of torsade de pointes (eg, bradycardia, hypokalemia, hypomagnesemia). Monitor potassium, magnesium, others if risk of electrolyte disturbances (eg, diarrhea); correct imbalance before starting. Avoid in significant cardiovascular disease (eg, arrhythmias). Evaluate cardiac function if symptoms of torsade de pointes occur (eg, dizziness, palpitations, syncope). Cardio- or cerebrovascular disease. Pre-existing low WBCs or history of leukopenia/neutropenia; monitor CBCs during 1st few months of treatment; discontinue if WBCs decline. Diabetes; monitor for hyperglycemia. Monitor weight. Risk of hypotension or seizures. History of breast cancer. Dysphagia. Exposure to extreme heat. Perform fall risk assessments when initiating and recurrently on long-term therapy. Reevaluate periodically. Write ℞ for smallest practical amount. Neonates: risk of extrapyramidal and/or withdrawal symptoms post delivery (due to exposure during 3rd-trimester pregnancy). Pregnancy. Nursing mothers: monitor infants.
Geodon Pharmacokinetics
See Literature
Geodon Interactions
Interactions
See Contraindications. May potentiate CNS drugs, antihypertensives. May antagonize levodopa, dopamine agonists. Extent of absorption and/or plasma levels may be affected by CYP3A4 inducers (eg, carbamazepine) or inhibitors (eg, ketoconazole). Correct hypokalemia, hypomagnesemia due to diuretics.
Geodon Adverse Reactions
Adverse Reactions
Somnolence, extrapyramidal syndrome, respiratory disorder, dizziness, akathisia, abnormal vision, asthenia, vomiting, nausea, rash, dystonia, postural hypotension, QTc prolongation, headache, weight gain, inj site reactions, hyperprolactinemia, dyslipidemia, hyperglycemia; rare: priapism, leukopenia, neutropenia, agranulocytosis (may be fatal).
Geodon Clinical Trials
See Literature
Geodon Note
Not Applicable
Geodon Patient Counseling
See Literature