Geodon

— THERAPEUTIC CATEGORIES —
  • Mood disorders
  • Psychosis

Geodon Generic Name & Formulations

General Description

Ziprasidone (as HCl) 20mg, 40mg, 60mg, 80mg; caps.

Pharmacological Class

Serotonin and dopamine antagonist.

See Also

    How Supplied

    Caps—60

    Manufacturer

    Generic Availability

    YES

    Geodon Indications

    Indications

    Acute treatment of manic or mixed episodes in bipolar disorder as monotherapy; or as an adjunct to lithium or valproate for maintenance treatment.

    Geodon Dosage and Administration

    Adult

    Swallow whole. Take with food. Initially 40mg twice daily; may increase on day 2 to 60mg or 80mg twice daily; usual range 40–80mg twice daily. Elderly: consider lower initial dose, slower titration.

    Children

    Not established.

    Geodon Contraindications

    Contraindications

    History of QT prolongation. Congenital long QT syndrome. Recent acute MI. Uncompensated heart failure. Concomitant drugs that cause QT prolongation, including dofetilide, sotalol, quinidine, other Class Ia and III antiarrhythmics, mesoridazine, thioridazine, chlorpromazine, droperidol, pimozide, sparfloxacin, gatifloxacin, moxifloxacin, halofantrine, mefloquine, pentamidine, arsenic trioxide, levomethadyl, dolasetron, probucol, tacrolimus.

    Geodon Boxed Warnings

    Boxed Warning

    Increased mortality in elderly patients with dementia-related psychosis.

    Geodon Warnings/Precautions

    Warnings/Precautions

    Increased mortality in elderly with dementia-related psychosis (not approved use). Concomitant use of oral and IM forms: not recommended. Renal (IM form) or hepatic impairment (both forms). Discontinue if QTc >500 msec persists, neuroleptic malignant syndrome, unexplained rash occurs, or if severe skin reactions (eg, Stevens-Johnson syndrome or DRESS) are suspected; consider discontinuing if tardive dyskinesia occurs. Conditions that increase risk of torsade de pointes (eg, bradycardia, hypokalemia, hypomagnesemia). Monitor potassium, magnesium, others if risk of electrolyte disturbances (eg, diarrhea); correct imbalance before starting. Avoid in significant cardiovascular disease (eg, arrhythmias). Evaluate cardiac function if symptoms of torsade de pointes occur (eg, dizziness, palpitations, syncope). Cardio- or cerebrovascular disease. Pre-existing low WBCs or history of leukopenia/neutropenia; monitor CBCs during 1st few months of treatment; discontinue if WBCs decline. Diabetes; monitor for hyperglycemia. Monitor weight. Risk of hypotension or seizures. History of breast cancer. Dysphagia. Exposure to extreme heat. Perform fall risk assessments when initiating and recurrently on long-term therapy. Reevaluate periodically. Write ℞ for smallest practical amount. Neonates: risk of extrapyramidal and/or withdrawal symptoms post delivery (due to exposure during 3rd-trimester pregnancy). Pregnancy. Nursing mothers: monitor infants.

    Geodon Pharmacokinetics

    See Literature

    Geodon Interactions

    Interactions

    See Contraindications. May potentiate CNS drugs, antihypertensives. May antagonize levodopa, dopamine agonists. Extent of absorption and/or plasma levels may be affected by CYP3A4 inducers (eg, carbamazepine) or inhibitors (eg, ketoconazole). Correct hypokalemia, hypomagnesemia due to diuretics.

    Geodon Adverse Reactions

    Adverse Reactions

    Somnolence, extrapyramidal syndrome, respiratory disorder, dizziness, akathisia, abnormal vision, asthenia, vomiting, nausea, rash, dystonia, postural hypotension, QTc prolongation, headache, weight gain, hyperprolactinemia, dyslipidemia, hyperglycemia; rare: priapism, leukopenia, neutropenia, agranulocytosis (may be fatal).

    Geodon Clinical Trials

    See Literature

    Geodon Note

    Not Applicable

    Geodon Patient Counseling

    See Literature

    Geodon Generic Name & Formulations

    General Description

    Ziprasidone (as HCl) 20mg, 40mg, 60mg, 80mg; caps.

    Pharmacological Class

    Serotonin and dopamine antagonist.

    How Supplied

    Caps—60; Single-use vials—10

    Manufacturer

    Generic Availability

    YES

    Geodon Indications

    Indications

    Schizophrenia.

    Geodon Dosage and Administration

    Adult

    Swallow whole. Take with food. Initially 20mg twice daily; may increase at intervals of at least 2 days; max 80mg twice daily. Elderly: consider lower initial dose, slower titration.

    Children

    Not established.

    Geodon Contraindications

    Contraindications

    History of QT prolongation. Congenital long QT syndrome. Recent acute MI. Uncompensated heart failure. Concomitant drugs that cause QT prolongation, including dofetilide, sotalol, quinidine, other Class Ia and III antiarrhythmics, mesoridazine, thioridazine, chlorpromazine, droperidol, pimozide, sparfloxacin, gatifloxacin, moxifloxacin, halofantrine, mefloquine, pentamidine, arsenic trioxide, levomethadyl, dolasetron, probucol, tacrolimus.

    Geodon Boxed Warnings

    Boxed Warning

    Increased mortality in elderly patients with dementia-related psychosis.

    Geodon Warnings/Precautions

    Warnings/Precautions

    Increased mortality in elderly with dementia-related psychosis (not approved use). Concomitant use of oral and IM forms: not recommended. Renal (IM form) or hepatic impairment (both forms). Discontinue if QTc >500 msec persists, neuroleptic malignant syndrome, unexplained rash occurs, or if severe skin reactions (eg, Stevens-Johnson syndrome or DRESS) are suspected; consider discontinuing if tardive dyskinesia occurs. Conditions that increase risk of torsade de pointes (eg, bradycardia, hypokalemia, hypomagnesemia). Monitor potassium, magnesium, others if risk of electrolyte disturbances (eg, diarrhea); correct imbalance before starting. Avoid in significant cardiovascular disease (eg, arrhythmias). Evaluate cardiac function if symptoms of torsade de pointes occur (eg, dizziness, palpitations, syncope). Cardio- or cerebrovascular disease. Pre-existing low WBCs or history of leukopenia/neutropenia; monitor CBCs during 1st few months of treatment; discontinue if WBCs decline. Diabetes; monitor for hyperglycemia. Monitor weight. Risk of hypotension or seizures. History of breast cancer. Dysphagia. Exposure to extreme heat. Perform fall risk assessments when initiating and recurrently on long-term therapy. Reevaluate periodically. Write ℞ for smallest practical amount. Neonates: risk of extrapyramidal and/or withdrawal symptoms post delivery (due to exposure during 3rd-trimester pregnancy). Pregnancy. Nursing mothers: monitor infants.

    Geodon Pharmacokinetics

    See Literature

    Geodon Interactions

    Interactions

    See Contraindications. May potentiate CNS drugs, antihypertensives. May antagonize levodopa, dopamine agonists. Extent of absorption and/or plasma levels may be affected by CYP3A4 inducers (eg, carbamazepine) or inhibitors (eg, ketoconazole). Correct hypokalemia, hypomagnesemia due to diuretics.

    Geodon Adverse Reactions

    Adverse Reactions

    Somnolence, extrapyramidal syndrome, respiratory disorder, dizziness, akathisia, abnormal vision, asthenia, vomiting, nausea, rash, dystonia, postural hypotension, QTc prolongation, headache, weight gain, inj site reactions, hyperprolactinemia, dyslipidemia, hyperglycemia; rare: priapism, leukopenia, neutropenia, agranulocytosis (may be fatal).

    Geodon Clinical Trials

    See Literature

    Geodon Note

    Not Applicable

    Geodon Patient Counseling

    See Literature