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Forfivo Xl Generic Name & Formulations
Legal Class
Rx
General Description
Bupropion HCl 450mg; ext-rel tabs.
Pharmacological Class
Aminoketone.
How Supplied
Tabs—30
Manufacturer
Generic Availability
NO
Forfivo Xl Indications
Indications
Major depressive disorder.
Forfivo Xl Dosage and Administration
Adult
Do not use for initiation treatment; use other bupropion forms for initial dose titration. Swallow whole. One tab (450mg) once daily. May be used in patients receiving 300mg/day of another bupropion forms for at least 2 weeks and requiring a 450mg/day dose. Taper dose using another bupropion form prior to stopping Forfivo XL. Switching from other bupropion forms at 450mg/day: give equivalent dose of Forfivo XL once daily. Switching to/from MAOIs: see full labeling.
Children
Not established.
Forfivo Xl Contraindications
Contraindications
Seizure disorders. Bulimia. Anorexia nervosa. During or within 14 days of MAOIs. Concomitant linezolid or IV methylene blue. Abrupt withdrawal of alcohol, benzodiazepines, barbiturates, antiepileptics. Other forms of bupropion-containing products.
Forfivo Xl Boxed Warnings
Boxed Warning
Suicidal thoughts and behaviors.
Forfivo Xl Warnings/Precautions
Warnings/Precautions
Increased risk of suicidal thinking and behavior in children, adolescents, and young adults; monitor all patients for clinical worsening or unusual behavioral changes. Monitor for neuropsychiatric adverse events (eg, behavioral changes, agitation, depression, suicidal ideation); discontinue if occurs. Pre-existing psychiatric disorders. Not for treating bipolar depression or for smoking cessation. Risk of seizures; discontinue if occurs: do not restart. Monitor BP prior to initiation and periodically during treatment. Bipolar disorder. Mania/hypomania. Angle-closure glaucoma. Unstable heart disease. CHF. Recent MI. Hepatic or renal impairment: not recommended. Reevaluate periodically. Write ℞ for smallest practical amount. Elderly. Pregnancy. Nursing mothers.
Forfivo Xl Pharmacokinetics
See Literature
Forfivo Xl Interactions
Interactions
See Contraindications. Do not start with concomitant linezolid or IV methylene blue; if treatment necessary, discontinue bupropion before starting. Monitor for 2 weeks or until 24hrs after last dose of linezolid or IV methylene blue, whichever comes first. Concomitant CYP2B6 inhibitors (eg, ticlopidine or clopidogrel): not recommended. Avoid alcohol. Caution with levodopa, amantadine. Caution with drugs that lower seizure threshold (eg, theophylline, antidiabetics, anorectics, CNS stimulants, systemic steroids, antidepressants, antipsychotics) or factors that lower seizure threshold (eg, opiate or cocaine addiction, excessive use of alcohol or sedatives). May be antagonized by CYP2B6 inducers (eg, ritonavir, lopinavir, efavirenz, carbamazepine, phenobarbital, phenytoin); may need bupropion dose increase. May potentiate drugs metabolized by CYP2D6 (eg, venlafaxine, nortriptyline, imipramine, desipramine, paroxetine, fluoxetine, sertraline, haloperidol, risperidone, thioridazine, metoprolol, propafenone, flecainide); consider dose reduction of these drugs. May antagonize tamoxifen. Monitor for hypertension with nicotine replacement. May cause false (+) urine immunoassay test results for amphetamines.
Forfivo Xl Adverse Reactions
Adverse Reactions
Dry mouth, nausea, insomnia, dizziness, pharyngitis, abdominal pain, agitation, anxiety, tremor, palpitation, sweating, tinnitus, myalgia, anorexia, urinary frequency, rash; hypertension, hypersensitivity (discontinue if occurs).
Forfivo Xl Clinical Trials
See Literature
Forfivo Xl Note
Not Applicable
Forfivo Xl Patient Counseling
See Literature
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