EVEKEO ODT Dosage & Rx Info | Uses, Side Effects

Evekeo Odt Generic Name & Formulations

Legal Class

CII

General Description

Amphetamine sulfate 5mg, 10mg, 15mg, 20mg; orally disintegrating tabs.

Pharmacological Class

CNS stimulant.

How Supplied

Blister card 5mg, 10mg, 15mg—30; 20mg—15, 30

Manufacturer

Arbor Pharmaceuticals, LLC

Generic Availability

Mechanism of Action

Amphetamines are non-catecholamine sympathomimetic amines with central nervous system (CNS) stimulant activity. The mode of therapeutic action in ADHD is not known.

Evekeo Odt Indications

Indications

Attention deficit hyperactivity disorder.

Evekeo Odt Dosage and Administration

Adult

Use other forms.

Children

<6yrs: not established. Individualize. Take in the AM. 6–17yrs: initially 5mg once or twice daily; give additional dose after 4–6hrs if needed. Titrate in increments of 5mg at weekly intervals based on response and tolerability. Usual max 40mg/day. Switching from Evekeo tabs: give on a mg-per-mg basis. Switching from other amphetamine products: see full labeling.

Evekeo Odt Contraindications

Contraindications

During or within 14 days of MAOIs.

Evekeo Odt Boxed Warnings

Boxed Warning

Abuse, misuse, and addiction.

Evekeo Odt Warnings/Precautions

Warnings/Precautions

High potential for abuse, misuse, and addiction; assess patient's risk before prescribing. Assess for presence of cardiac disease before initiating. Avoid in known structural cardiac abnormalities, cardiomyopathy, serious arrhythmias, coronary artery disease, or other cardiac disease. Pre-existing psychotic disorder. Bipolar disorder. Screen for risk factors in developing manic episode prior to initiation. Consider discontinuing if new psychotic/manic symptoms occur. Monitor for seizures, serotonin syndrome; discontinue if occurs. Assess family history and evaluate for tics or Tourette’s syndrome before initiating; monitor for emergence or worsening, and discontinue if clinically appropriate. Peripheral vasculopathy, including Raynaud's phenomenon; monitor for digital changes. Monitor BP, HR, growth in children. Write ℞ for smallest practical amount. Reevaluate periodically. Pregnancy: monitor for neonatal withdrawal symptoms. Nursing mothers: not recommended.

Evekeo Odt Pharmacokinetics

Absorption

Median Tmax (range) was reached: ~3.5 (2–8) hours for dextroamphetamine; 3.0 (1–6) hours for levoamphetamine.

Metabolism

CYP2D6, oxidative deamination.

Elimination

Renal. Half-life: 10 hours (dextroamphetamine); 11.7 hours (levoamphetamine).

Evekeo Odt Interactions

Interactions

See Contraindications. Hypertensive crisis with MAOIs (including linezolid, IV methylene blue). Increased risk of serotonin syndrome with serotonergic drugs (eg, SSRIs, SNRIs, TCAs, triptans, fentanyl, lithium, tramadol, tryptophan, busprione, St. John's wort), CYP2D6 inhibitors (eg, paroxetine, fluoxetine, quinidine, ritonavir); consider alternatives; if needed, initiate with lower doses and monitor. Potentiated by alkalinizers (eg, sodium bicarbonate, PPIs, acetazolamide, some thiazides). Antagonized by acidifiers (eg, ascorbic acid). May potentiate TCAs or sympathomimetics; adjust dose or use alternatives. May interfere with urinary steroid tests.

Evekeo Odt Adverse Reactions

Adverse Reactions

Decreased appetite, insomnia, abdominal pain, affect lability, injury; hypertension, tachycardia.

Evekeo Odt Clinical Trials

See Literature

Evekeo Odt Note

Notes

To register pregnant patients in the National Pregnancy Registry for Psychostimulants, call (866) 961-2388.

Evekeo Odt Patient Counseling