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Doxepin Hcl Capsules Generic Name & Formulations
Legal Class
Rx
General Description
Doxepin (as HCl) 10mg, 25mg, 50mg, 75mg, 100mg, 150mg; caps.
Pharmacological Class
Tricyclic.
See Also
How Supplied
Contact supplier.
Manufacturer
Doxepin Hcl Capsules Indications
Indications
Anxiety.
Doxepin Hcl Capsules Dosage and Administration
Adult
Soln: dilute with 4oz juice, water, or milk. Mild: 25–50mg/day. Mild-to-moderate: initially 75mg/day; range 75–150mg/day. Severe: max 300mg/day. May give as single (up to 150mg) or divided doses; 150mg caps for maintenance only.
Children
Not recommended.
Doxepin Hcl Capsules Contraindications
Contraindications
Urinary retention. Glaucoma.
Doxepin Hcl Capsules Boxed Warnings
Not Applicable
Doxepin Hcl Capsules Warnings/Precautions
Warnings/Precautions
Increased risk of suicidal thinking and behavior in children, adolescents, and young adults; monitor for clinical worsening and unusual changes. Screen for bipolar disorder. Cardiovascular disease. Angle-closure glaucoma. Seizures. Psychosis. Poor metabolizers (those with reduced CYP2D6 activity). Avoid abrupt cessation. Write ℞ for smallest practical amount. Elderly. Pregnancy. Nursing mothers.
Doxepin Hcl Capsules Pharmacokinetics
See Literature
Doxepin Hcl Capsules Interactions
Interactions
Hyperpyretic crisis, convulsions, death with MAOIs; discontinue at least 14 days prior to initiating doxepin. Potentiated by CYP2D6 inhibitors (eg, quinidine, cimetidine, phenothiazines, SSRIs, Type IC antiarrhythmics); may need dose reduction. Do not initiate within 5 weeks of discontinuing fluoxetine. Avoid alcohol. May block guanethidine.
Doxepin Hcl Capsules Adverse Reactions
Adverse Reactions
CNS effects (eg, drowsiness, overstimulation, extrapyramidal symptoms), anticholinergic effects, hypotension, GI upset, photosensitivity, endocrine effects.
Doxepin Hcl Capsules Clinical Trials
See Literature
Doxepin Hcl Capsules Note
Notes
Formerly known under the brand name Sinequan.
Doxepin Hcl Capsules Patient Counseling
See Literature
Doxepin Hcl Capsules Generic Name & Formulations
Legal Class
Rx
General Description
Doxepin (as HCl) 10mg, 25mg, 50mg, 75mg, 100mg, 150mg; caps.
Pharmacological Class
Tricyclic.
See Also
How Supplied
Contact supplier.
Manufacturer
Doxepin Hcl Capsules Indications
Indications
Depression.
Doxepin Hcl Capsules Dosage and Administration
Adult
Soln: dilute with 4oz juice, water, or milk. Mild: 25–50mg/day. Mild-to-moderate: initially 75mg/day; range 75–150mg/day. Severe: max 300mg/day. May give as single (up to 150mg) or divided doses; 150mg caps for maintenance only.
Children
Not recommended.
Doxepin Hcl Capsules Contraindications
Contraindications
Urinary retention. Glaucoma.
Doxepin Hcl Capsules Boxed Warnings
Not Applicable
Doxepin Hcl Capsules Warnings/Precautions
Warnings/Precautions
Increased risk of suicidal thinking and behavior in children, adolescents, and young adults; monitor for clinical worsening and unusual changes. Screen for bipolar disorder. Cardiovascular disease. Angle-closure glaucoma. Seizures. Psychosis. Poor metabolizers (those with reduced CYP2D6 activity). Avoid abrupt cessation. Write ℞ for smallest practical amount. Elderly. Pregnancy. Nursing mothers.
Doxepin Hcl Capsules Pharmacokinetics
See Literature
Doxepin Hcl Capsules Interactions
Interactions
Hyperpyretic crisis, convulsions, death with MAOIs; discontinue at least 14 days prior to initiating doxepin. Potentiated by CYP2D6 inhibitors (eg, quinidine, cimetidine, phenothiazines, SSRIs, Type IC antiarrhythmics); may need dose reduction. Do not initiate within 5 weeks of discontinuing fluoxetine. Avoid alcohol. May block guanethidine.
Doxepin Hcl Capsules Adverse Reactions
Adverse Reactions
CNS effects (eg, drowsiness, overstimulation, extrapyramidal symptoms), anticholinergic effects, hypotension, GI upset, photosensitivity, endocrine effects.
Doxepin Hcl Capsules Clinical Trials
See Literature
Doxepin Hcl Capsules Note
Notes
Formerly known under the brand name Sinequan.
Doxepin Hcl Capsules Patient Counseling
See Literature
