Daytrana Generic Name & Formulations
Legal Class
General Description
Pharmacological Class
How Supplied
Manufacturer
Generic Availability
Mechanism of Action
Daytrana Indications
Indications
Daytrana Dosage and Administration
Adult
Children
Daytrana Contraindications
Contraindications
During or within 14 days of MAOIs.
Daytrana Boxed Warnings
Boxed Warning
Abuse, misuse, and addiction.
Daytrana Warnings/Precautions
Warnings/Precautions
High potential for abuse, misuse, and addiction; assess patient's risk before prescribing. Assess for presence of cardiac disease before initiating. Avoid in known structural cardiac abnormalities, cardiomyopathy, serious arrhythmias, coronary artery disease, or other cardiac disease. Pre-existing psychotic disorder. Bipolar disorder. Screen for risk factors in developing manic episode prior to initiation. Consider discontinuing if new psychotic/manic symptoms occur. Seizure disorder. Risk for acute angle closure glaucoma. History of increased IOP or open angle glaucoma; monitor closely. Assess family history and evaluate for tics or Tourette’s syndrome before initiating; monitor for emergence or worsening, and discontinue if clinically appropriate. Peripheral vasculopathy, including Raynaud's phenomenon; monitor for digital changes. History of vitiligo. Monitor BP, HR, growth in children. Periodically monitor CBCs, differential, platelet counts during prolonged therapy. Monitor for signs of skin depigmentation; discontinue if chemical leukoderma develops. Discontinue if contact sensitization is suspected; may develop systemic sensitization with other MPH formulations (see full labeling). Avoid exposing patch to direct external heat sources. Pregnancy. Nursing mothers: monitor infants.
Daytrana Pharmacokinetics
Absorption
Peak plasma levels: reached at about 10 hours (after single application); 8 hours (after repeat applications).
The rate and extent of absorption are increased when applied to inflamed skin or when heat is applied compared with intact skin.
Elimination
Daytrana Interactions
Interactions
See Contraindications. Hypertensive crisis with MAOIs. May potentiate coumarin anticoagulants, anticonvulsants (eg, phenobarbital, phenytoin, primidone), tricyclics (eg, imipramine, clomipramine, desipramine), SSRIs; may need dose adjustments. May antagonize antihypertensive agents; monitor and adjust dose of antihypertensives as needed. Caution with pressor agents. Concomitant halogenated anesthetics may increase the risk of sudden BP and HR increase during surgery; avoid use. Concomitant risperidone may increase risk of extrapyramidal symptoms; monitor.
Daytrana Adverse Reactions
Adverse Reactions
Daytrana Clinical Trials
See Literature
Daytrana Note
Not Applicable
Daytrana Patient Counseling
See Literature