Daytrana

— THERAPEUTIC CATEGORIES —
  • ADHD

Daytrana Generic Name & Formulations

General Description

Methylphenidate 10mg, 15mg, 20mg, 30mg; delivered over 9hrs; transdermal patches.

Pharmacological Class

CNS stimulant.

How Supplied

Patches—30

Manufacturer

Generic Availability

NO

Mechanism of Action

The mode of therapeutic action of methylphenidate HCl in ADHD is not known. Methylphenidate is thought to block the reuptake of norepinephrine and dopamine into the presynaptic neuron and increases the release of these monoamines into the extraneuronal space.

Daytrana Indications

Indications

Attention deficit hyperactivity disorder.

Daytrana Dosage and Administration

Adult

Not applicable.

Children

<6yrs: not established. 6–17yrs: Initially apply one 10mg patch to hip 2hrs before desired effect, remove 9hrs after application; may remove earlier if shorter duration of effect or late day side effects appear. May titrate dose at 1-week intervals. Reevaluate periodically. Rotate application sites.

Daytrana Contraindications

Contraindications

During or within 14 days of MAOIs.

Daytrana Boxed Warnings

Boxed Warning

Abuse, misuse, and addiction.

Daytrana Warnings/Precautions

Warnings/Precautions

High potential for abuse, misuse, and addiction; assess patient's risk before prescribing. Assess for presence of cardiac disease before initiating. Avoid in known structural cardiac abnormalities, cardiomyopathy, serious arrhythmias, coronary artery disease, or other cardiac disease. Pre-existing psychotic disorder. Bipolar disorder. Screen for risk factors in developing manic episode prior to initiation. Consider discontinuing if new psychotic/manic symptoms occur. Seizure disorder. Risk for acute angle closure glaucoma. History of increased IOP or open angle glaucoma; monitor closely. Assess family history and evaluate for tics or Tourette’s syndrome before initiating; monitor for emergence or worsening, and discontinue if clinically appropriate. Peripheral vasculopathy, including Raynaud's phenomenon; monitor for digital changes. History of vitiligo. Monitor BP, HR, growth in children. Periodically monitor CBCs, differential, platelet counts during prolonged therapy. Monitor for signs of skin depigmentation; discontinue if chemical leukoderma develops. Discontinue if contact sensitization is suspected; may develop systemic sensitization with other MPH formulations (see full labeling). Avoid exposing patch to direct external heat sources. Pregnancy. Nursing mothers: monitor infants.

Daytrana Pharmacokinetics

Absorption

Peak plasma levels: reached at about 10 hours (after single application); 8 hours (after repeat applications).

The rate and extent of absorption are increased when applied to inflamed skin or when heat is applied compared with intact skin.

Metabolism

Primarily by de-esterification.

Elimination

Half-life: ~4–5 hours (d-methylphenidate); ~1.4–2.9 hours (l-methylphenidate).

Daytrana Interactions

Interactions

See Contraindications. Hypertensive crisis with MAOIs. May potentiate coumarin anticoagulants, anticonvulsants (eg, phenobarbital, phenytoin, primidone), tricyclics (eg, imipramine, clomipramine, desipramine), SSRIs; may need dose adjustments. May antagonize antihypertensive agents; monitor and adjust dose of antihypertensives as needed. Caution with pressor agents. Concomitant halogenated anesthetics may increase the risk of sudden BP and HR increase during surgery; avoid use. Concomitant risperidone may increase risk of extrapyramidal symptoms; monitor.

Daytrana Adverse Reactions

Adverse Reactions

Application site reactions (eg, erythema), decreased appetite, insomnia, nausea, vomiting, weight loss, tics, affect lability, anorexia, dizziness, abdominal pain; priapism, hypertension, tachycardia, visual disturbances.

Daytrana Clinical Trials

See Literature

Daytrana Note

Not Applicable

Daytrana Patient Counseling

See Literature