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Buspirone Generic Name & Formulations
Legal Class
Rx
General Description
Buspirone HCl 5mg, 10mg, 15mg+, 30mg+; scored (+bi/trisected) tabs.
Pharmacological Class
Azaspirone.
How Supplied
Contact supplier.
Manufacturer
Buspirone Indications
Indications
Anxiety.
Buspirone Dosage and Administration
Adult
Take consistently with regard to food. Initially 7.5mg twice daily, may increase by 5mg/day every 2–3 days. Usual range: 20–30mg/day; max 60mg/day.
Children
<6yrs: not recommended. 6–17yrs: doses of 7.5–30mg twice daily have been used.
Buspirone Contraindications
Contraindications
Concomitant MAOIs.
Buspirone Boxed Warnings
Not Applicable
Buspirone Warnings/Precautions
Warnings/Precautions
Severe renal or hepatic impairment: not recommended. Elderly. Labor & delivery. Pregnancy (Cat.B). Nursing mothers: not recommended.
Buspirone Pharmacokinetics
See Literature
Buspirone Interactions
Interactions
Hypertensive crisis with MAOIs: see Contraindications. Avoid alcohol, large amounts of grapefruit juice. Caution with other CNS drugs. May potentiate haloperidol, diazepam, nefazodone. Potentiated by nefazodone, verapamil, diltiazem, erythromycin, itraconazole, ketoconazole, ritonavir, other CYP3A4 inhibitors (use lower initial dose). Antagonized by rifampin, dexamethasone, phenytoin, phenobarbital, carbamazepine, other CYP3A4 inducers.
Buspirone Adverse Reactions
Adverse Reactions
Dizziness, GI upset, headache, nervousness, CNS or emotional effects, nonspecific chest pain, tinnitus, dream disturbances.
Buspirone Clinical Trials
See Literature
Buspirone Note
Not Applicable
Buspirone Patient Counseling
See Literature
