Share on Facebook
Share on Twitter
Share on LinkedIn
Share by Email
Print
Bupropion Hcl Tablets Generic Name & Formulations
Legal Class
Rx
General Description
Bupropion HCl 75mg, 100mg.
Pharmacological Class
Aminoketone.
See Also
How Supplied
XL tabs 150mg—30, 90; 300mg—30; SR tabs—60; Tabs—contact supplier
Manufacturer
Generic Availability
YES
Bupropion Hcl Tablets Indications
Indications
Major depressive disorder (MDD).
Bupropion Hcl Tablets Dosage and Administration
Adult
Swallow whole. Avoid bedtime dosing. ≥18yrs: initially 100mg twice daily for at least 3 days; if tolerated, increase to 100mg 3 times daily at least 6hrs apart; max increase 100mg/day per 3-day period. May increase after several weeks to max 450mg/day in 3 divided doses; max single dose: 150mg (give 400mg/day as 100mg 4 times daily at least 4hrs apart). Moderate to severe hepatic impairment: max 75mg once daily. Renal or mild hepatic impairment: consider reduced dose and/or dose frequency. Switching to Wellbutrin XL: give same total daily dose.
Children
<18yrs: not established.
Bupropion Hcl Tablets Contraindications
Contraindications
Seizure disorders. Bulimia. Anorexia nervosa. During or within 14 days of discontinuing MAOIs. Concomitant linezolid or IV methylene blue. Abrupt withdrawal of alcohol, benzodiazepines, barbiturates, or antiepileptics. Other forms of bupropion (eg, Zyban).
Bupropion Hcl Tablets Boxed Warnings
Boxed Warning
Suicidal thoughts and behaviors.
Bupropion Hcl Tablets Warnings/Precautions
Warnings/Precautions
Not for treating bipolar depression or for smoking cessation. Increased risk of suicidal thinking and behavior in children, adolescents, and young adults; monitor all patients for clinical worsening or unusual behavioral changes. Monitor for neuropsychiatric adverse events (eg, behavioral changes, agitation, depression, suicidal ideation); evaluate and consider treatment continuation under closer monitoring, or discontinuation if occur. Pre-existing psychiatric disorders. Bipolar disorder. Mania/hypomania. Psychosis. Risk of seizures; discontinue if seizure occurs: do not restart. Angle-closure glaucoma. Unstable heart disease. CHF. Recent MI. Monitor BP before initiating and periodically during treatment. Hepatic or renal impairment (monitor closely). Reevaluate periodically. Maintain at lowest effective dose. Write ℞ for smallest practical amount. Elderly. Pregnancy. Nursing mothers.
Bupropion Hcl Tablets Pharmacokinetics
See Literature
Bupropion Hcl Tablets Interactions
Interactions
See Contraindications. Do not start with concomitant linezolid or IV methylene blue; if treatment necessary, discontinue bupropion before starting. Monitor for 2 weeks or until 24hrs after last dose of linezolid or IV methylene blue, whichever comes first. Avoid alcohol. Levodopa, amantadine may increase CNS toxicity. Caution with drugs that lower seizure threshold (eg, theophylline, antidiabetics, anorectics, CNS stimulants, systemic steroids, tricyclic antidepressants, antipsychotics) or factors that lower seizure threshold (eg, opiate or cocaine addiction, excessive use of alcohol or sedatives). Caution with CYP2B6 inhibitors (eg, ticlopidine, clopidogrel) or drugs metabolized by CYP2D6 including antidepressants (eg, venlafaxine, nortriptyline, imipramine, desipramine, paroxetine, fluoxetine, sertraline), antipsychotics (eg, haloperidol, risperidone, thioridazine), β-blockers (eg, metoprolol), Class 1C antiarrhythmics (eg, propafenone, flecainide); consider dose reduction. Caution with CYP2B6 inducers (eg, ritonavir, lopinavir, efavirenz, carbamazepine, phenobarbital, phenytoin), tamoxifen; consider dose increase. May antagonize digoxin; monitor. May cause false (+) urine immunoassay test results for amphetamine.
Bupropion Hcl Tablets Adverse Reactions
Adverse Reactions
Dry mouth, nausea, insomnia, dizziness, pharyngitis, abdominal pain, agitation, anxiety, tremor, palpitation, sweating, tinnitus, myalgia, anorexia, urinary frequency, rash (rarely may be serious, eg, erythema multiforme, Stevens-Johnson syndrome), headache, blurred vision, tachycardia; hypertension.
Bupropion Hcl Tablets Clinical Trials
See Literature
Bupropion Hcl Tablets Note
Not Applicable
Bupropion Hcl Tablets Patient Counseling
See Literature
