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Amoxapine Generic Name & Formulations
Legal Class
Rx
General Description
Amoxapine 25mg, 50mg, 100mg, 150mg; tabs.
Pharmacological Class
Dibenzoxazepine.
How Supplied
Tabs 25mg, 50mg, 100mg—100; 150mg—30
Manufacturer
Amoxapine Indications
Indications
Depression in patients with neurotic or reactive depressive disorders as well as endogenous and psychotic depressions. Depression accompanied by anxiety or agitation.
Amoxapine Dosage and Administration
Adult
Initially 50mg 2–3 times daily; may increase to 100mg 2–3 times daily by the end of the first week. May increase above 300mg/day if dose has been ineffective for a period of at least 2 weeks. Maintenance: when effective dosage established, may give as single dose at bedtime (max 300mg). Elderly: initially 25mg 2–3 times daily; may increase by the end of the first week to 50mg 2–3 times daily. May increase carefully up to 300mg/day if necessary.
Children
Not recommended.
Amoxapine Contraindications
Contraindications
Within 14 days of MAOIs. During acute recovery phase following MI.
Amoxapine Boxed Warnings
Not Applicable
Amoxapine Warnings/Precautions
Warnings/Precautions
Monitor for clinical worsening, suicidality, and unusual changes in behavior, esp. during initial few months of treatment and during dose changes. Screen for bipolar disorder prior to initiating therapy. Urinary retention. Angle-closure glaucoma. Increased intraocular pressure. Cardiovascular disorders (monitor closely). Seizure disorders. Discontinue if rash, fever, tardive dyskinesia or neuroleptic malignant syndrome develop. Write ℞ for smallest practical amount. Pregnancy (Cat.C). Nursing mothers.
Amoxapine Pharmacokinetics
See Literature
Amoxapine Interactions
Interactions
During or within 5 weeks of fluoxetine. Hyperpyretic crises, severe convulsions, and death with MAOIs (see Contraindications). Potentiates alcohol, barbiturates, other CNS depressants. Paralytic ileus with anticholinergics. Monitor serum levels with CYP450 2D6 inhibitors (eg, quinidine, cimetidine, phenothiazines, propafenone, flecainide, others: see literature). Caution with concomitant electroshock therapy.
Amoxapine Adverse Reactions
Adverse Reactions
Drowsiness, dry mouth, constipation, blurred vision, CNS effects (eg, anxiety, insomnia, restlessness, nervousness, palpitations, tremors, confusion, excitement, nightmares, ataxia, alterations in EEG patterns), edema, rash, elevated prolactin levels, nausea, dizziness, headache, fatigue, weakness, excessive appetite, increased perspiration.
Amoxapine Clinical Trials
See Literature
Amoxapine Note
Notes
Formerly known under the brand name Asendin.
Amoxapine Patient Counseling
See Literature
