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Amitriptyline Generic Name & Formulations
Legal Class
Rx
General Description
Amitriptyline HCl 10mg, 25mg, 50mg, 75mg, 100mg, 150mg; tabs.
Pharmacological Class
Tricyclic.
How Supplied
Contact supplier.
Manufacturer
Amitriptyline Indications
Indications
Depression especially endogenous.
Amitriptyline Dosage and Administration
Adult
Initially 75mg daily in divided doses or 50–100mg daily at bedtime; max 150mg daily. Elderly and adolescents: reduce dose.
Children
Not recommended.
Amitriptyline Contraindications
Contraindications
During or within 14 days of MAOIs. Acute post MI.
Amitriptyline Boxed Warnings
Not Applicable
Amitriptyline Warnings/Precautions
Warnings/Precautions
History of seizures, urinary retention, glaucoma. Cardiovascular disease. Suicidal tendencies. Surgery. ECT. Psychosis. Hyperthyroidism. Liver dysfunction. Diabetes. Gradually reduce to lowest effective maintenance dose. Elderly. Pregnancy (Cat.C). Nursing mothers: not recommended.
Amitriptyline Pharmacokinetics
See Literature
Amitriptyline Interactions
Interactions
During or within 5 weeks of fluoxetine. Hyperpyretic crises, severe convulsions, and death with MAOIs (see Contraindications). May block guanethidine. Potentiates alcohol, barbiturates, other CNS depressants. Delirium with disulfiram, ethchlorvynol. Paralytic ileus with anticholinergics. Hyperpyrexia with anticholinergics, sympathomimetics. Monitor serum levels with CYP450 inhibitors (eg, quinidine, cimetidine, phenothiazines, propafenone, flecainide, others: see literature).
Amitriptyline Adverse Reactions
Adverse Reactions
Drowsiness, anticholinergic effects, CNS overstimulation, arrhythmias, stroke, coma, confusion, extrapyramidal symptoms, hypo- or hypertension, nausea, fatigue, rash, increased perspiration, headache, photosensitivity, edema, blood dyscrasias, alopecia, libido changes, changes in blood sugar; women: breast enlargement, galactorrhea; men: testicular swelling, gynecomastia.
Amitriptyline Clinical Trials
See Literature
Amitriptyline Note
Notes
Formerly known under the brand name Elavil.
Amitriptyline Patient Counseling
See Literature
