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Zimhi Generic Name & Formulations
Legal Class
Rx
General Description
Naloxone HCl 5mg/0.5mL; per syringe; soln for IM or SC inj.
Pharmacological Class
Opioid antagonist.
How Supplied
Single-dose prefilled syringe—1, 2
Manufacturer
Generic Availability
NO
Zimhi Indications
Indications
Emergency treatment of opioid overdose, as manifested by respiratory and/or CNS depression.
Zimhi Dosage and Administration
Adults and Children
<1yr: Pinch thigh muscle while administering; monitor inj site for residual needle parts and/or infection. ≥1yr: Inject IM or SC into the anterolateral aspect of the thigh (through clothing, if necessary) according to label instructions. All: may give additional doses (using a new syringe) every 2–3mins until desired response or emergency medical assistance available; continue surveillance. Repeated doses depending on amount, type, and route of administration of the opioid being antagonized may be required.
Zimhi Contraindications
Not Applicable
Zimhi Boxed Warnings
Not Applicable
Zimhi Warnings/Precautions
Warnings/Precautions
Not a substitute for emergency medical care. Risk of recurrent respiratory and CNS depression. Seek immediate emergency medical assistance after the first dose. Have other resuscitative measures available. Known or suspected opioid dependence; abrupt reversal may precipitate acute withdrawal syndrome. Post-op use in pre-existing cardiac disorders; monitor. Elderly. Pregnancy. Nursing mothers.
Zimhi Pharmacokinetics
See Literature
Zimhi Interactions
Interactions
Caution with cardiotoxic drugs. Incomplete reversal of partial agonists or mixed agonists/antagonists (eg, buprenorphine, pentazocine); may require higher naloxone dose.
Zimhi Adverse Reactions
Adverse Reactions
Nausea, dizziness, lightheadedness, elevated bilirubin; precipitation of severe opioid withdrawal.
Zimhi Clinical Trials
See Literature
Zimhi Note
Not Applicable
Zimhi Patient Counseling
See Literature
