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Vistogard Generic Name & Formulations
Legal Class
Rx
General Description
Uridine triacetate 10g; oral granules (95% w/w); per pkt; orange-flavored.
Pharmacological Class
Pyrimidine analog.
How Supplied
Single-use packets—4, 20
Manufacturer
Generic Availability
NO
Vistogard Indications
Indications
Emergency treatment following a fluorouracil (5-FU) or capecitabine overdose regardless of the presence of symptoms or exhibits early-onset, severe or life-threatening toxicity affecting the cardiac or central nervous system, and/or early-onset, unusually severe adverse reactions within 96hrs following the end of 5-FU or capecitabine administration.
Limitations of Use
Not for non-emergent treatment of adverse reactions associated with 5-FU or capecitabine. Safety and efficacy not been established for initiation >96hrs after 5-FU or capecitabine therapy.
Vistogard Dosage and Administration
Adult
10g (1pkt) every 6hrs for 20 doses. Mix in 3–4oz of applesauce, pudding or yogurt and ingest within 30mins; do not chew granules. Drink at least 4oz of water. Also: can give via NG tube or G-tube if necessary: see full labeling.
Children
Base dose on body surface area; see full labeling. 6.2g/m2 (max 10g) per dose every 6hrs for 20 doses. Mix in 3–4oz of applesauce, pudding or yogurt and ingest within 30mins; do not chew granules. Drink at least 4oz of water. Also: can give via NG tube or G-tube if necessary: see full labeling.
Vistogard Contraindications
Not Applicable
Vistogard Boxed Warnings
Not Applicable
Vistogard Warnings/Precautions
Warnings/Precautions
Pregnancy. Nursing mothers.
Vistogard Pharmacokinetics
See Literature
Vistogard Interactions
Not Applicable
Vistogard Adverse Reactions
Adverse Reactions
Vomiting, nausea, diarrhea.
Vistogard Clinical Trials
See Literature
Vistogard Note
Not Applicable
Vistogard Patient Counseling
See Literature
