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Opvee Generic Name & Formulations
Legal Class
General Description
Pharmacological Class
How Supplied
Single-dose nasal spray—2
Manufacturer
Generic Availability
NO
Mechanism of Action
Opvee is an antagonist at opioid receptors.
Opvee Indications
Indications
Emergency treatment of known or suspected overdose induced by natural or synthetic opioids in patients ≥12yrs, as manifested by respiratory and/or CNS depression.
Opvee Dosage and Administration
Adults and Children
<12yrs: not established. ≥12yrs: Give as single spray intranasally into the nostril. May give additional doses (using a new nasal spray) every 2–5mins if unresponsive or relapses into respiratory depression.
Opvee Contraindications
Not Applicable
Opvee Boxed Warnings
Not Applicable
Opvee Warnings/Precautions
Warnings/Precautions
Not a substitute for emergency medical care. Seek immediate emergency medical assistance after the first dose. Risk for recurrent respiratory and CNS depression. May precipitate severe opioid withdrawal. Post-op use in preexisting cardiac disorders; monitor. Risk for opioid overdose from attempts to overcome blockade. Elderly. Pregnancy; monitor for neonatal withdrawal symptoms. Nursing mothers.
Opvee Pharmacokinetics
Elimination
Renal, fecal. Half-life: 11.4 hours. Apparent clearance: 75.7 L/hr.
Opvee Interactions
Interactions
Caution with concomitant cardiotoxic drugs. Incomplete reversal of buprenorphine or pentazocine; may require repeated doses.
Opvee Adverse Reactions
Adverse Reactions
Nasal discomfort, headache, nausea, dizziness, hot flush, vomiting, anxiety, fatigue, nasal congestion, throat irritation, rhinalgia, decreased appetite, dysgeusia, erythema, hyperhidrosis; acute withdrawal syndrome.
Opvee Clinical Trials
See Literature
Opvee Note
Not Applicable
Opvee Patient Counseling
See Literature
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