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Narcan Nasal Spray Generic Name & Formulations
Legal Class
OTC
General Description
Naloxone HCl 4mg; per spray; contains benzalkonium chloride.
Pharmacological Class
Opioid antagonist.
How Supplied
Single-dose nasal spray—2
Manufacturer
Generic Availability
YES
Mechanism of Action
Naloxone hydrochloride antagonizes opioid effects by competing for the same receptor sites. It reverses the effects of opioids, including respiratory depression, sedation and hypotension. It can also reverse the psychotomimetic and dysphoric effects of agonist-antagonists such as pentazocine.
Narcan Nasal Spray Indications
Indications
Reversal of known or suspected opioid overdose, including respiratory and/or CNS depression.
Narcan Nasal Spray Dosage and Administration
Adults and Children
Give as single spray intranasally into one nostril. May give additional doses (using a new nasal spray) every 2–3mins in alternate nostrils if unresponsive or relapses into respiratory depression.
Narcan Nasal Spray Contraindications
Not Applicable
Narcan Nasal Spray Boxed Warnings
Not Applicable
Narcan Nasal Spray Warnings/Precautions
Warnings/Precautions
Not a substitute for emergency medical care. Seek immediate emergency medical assistance after the first dose. Known or suspected opioid dependence; abrupt reversal may precipitate acute withdrawal syndrome. Monitor patients with satisfactory response due to long duration of some narcotics. Post-op use in preexisting cardiac disorders; monitor. Have other resuscitative measures available. Elderly. Pregnancy; monitor for neonatal withdrawal symptoms. Nursing mothers.
Narcan Nasal Spray Pharmacokinetics
Elimination
Renal. Half-life: 2.08 hours.
Narcan Nasal Spray Interactions
Interactions
Caution with cardiotoxic drugs. Incomplete reversal of buprenorphine or pentazocine; may require higher naloxone dose.
Narcan Nasal Spray Adverse Reactions
Adverse Reactions
Increased BP, musculoskeletal pain, headache, nasal effects (eg, dryness, edema, congestion, inflammation); opioid withdrawal.
Narcan Nasal Spray Clinical Trials
See Literature
Narcan Nasal Spray Note
Not Applicable
Narcan Nasal Spray Patient Counseling
See Literature
