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Naltrexone Generic Name & Formulations
Legal Class
Rx
General Description
Naltrexone HCl 50mg; scored tabs.
Pharmacological Class
Opioid antagonist.
How Supplied
Contact supplier
Manufacturer
Naltrexone Indications
Indications
Adjunct in treatment of alcohol or narcotic dependence.
Naltrexone Dosage and Administration
Adult
Confirm 7–10 day opioid-free period, if questionable do Narcan challenge test (see full labeling). ≥18yrs: Alcoholism: 50mg daily. Narcotic dependence: Initially 25mg, if no withdrawal symptoms increase to 50mg daily; alternative dosing schedules: see full labeling.
Children
<18yrs: not recommended.
Naltrexone Contraindications
Contraindications
Concomitant opioids, current opioid dependence, or acute opioid withdrawal. Failed Narcan challenge test or (+) urine screen for opioids. Acute hepatitis. Liver failure.
Naltrexone Boxed Warnings
Not Applicable
Naltrexone Warnings/Precautions
Warnings/Precautions
Liver disease. Monitor liver function. Warn patients of danger of attempting to overcome opiate blockade. Severe renal dysfunction. Possible acute abstinence syndrome. Depression. Suicidal ideation. Pregnancy (Cat.C). Nursing mothers.
Naltrexone Pharmacokinetics
See Literature
Naltrexone Interactions
Interactions
Thioridazine increases sedation. Antagonizes opioids (eg, antitussives, antidiarrheals, analgesics). Disulfiram.
Naltrexone Adverse Reactions
Adverse Reactions
Hepatotoxicity, withdrawal reactions; others, see full labeling.
Naltrexone Clinical Trials
See Literature
Naltrexone Note
Notes
Formerly known under the brand name Revia.
Naltrexone Patient Counseling
See Literature
