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Naloxone Hcl Generic Name & Formulations
Legal Class
Rx
General Description
Naloxone 0.4mg/mL, 1mg/mL; IV, IM or SC inj; amps (paraben-free); vials.
Pharmacological Class
Opioid antagonist.
How Supplied
Contact supplier.
Manufacturer
Naloxone Hcl Indications
Indications
Reversal of opioid depression, including respiratory. Diagnosis of acute opioid overdose.
Naloxone Hcl Dosage and Administration
Adult
See full labeling. Post-op: 0.1–0.2mg IV, IM or SC, repeat 2–3 mins until desired response. Overdose: 0.4–2mg IV, IM or SC, repeat 2–3 mins; if no response after 10mg reevaluate. Both may require repeated doses depending on duration of narcotic activity.
Children
See full labeling. Post-op: 0.005–0.01mg/kg IV, IM or SC, repeat 2–3 mins until desired response. Overdose: 0.01mg/kg initially; if inadequate response give 0.1mg/kg body weight. Neonates, post-op: 0.01mg/kg, repeat 2–3 mins until desired response.
Naloxone Hcl Contraindications
Not Applicable
Naloxone Hcl Boxed Warnings
Not Applicable
Naloxone Hcl Warnings/Precautions
Warnings/Precautions
Known or suspected opioid dependence; abrupt reversal may precipitate acute withdrawal syndrome. Monitor patients with satisfactory response due to long duration of some narcotics. Post-op use in pre-existing cardiac disease. Have other resuscitative measures available. Renal or hepatic insufficiency. Elderly. Pregnancy (Cat.C). Nursing mothers.
Naloxone Hcl Pharmacokinetics
See Literature
Naloxone Hcl Interactions
Interactions
Caution with cardiotoxic drugs. Incomplete reversal of buprenorphine or pentazocine; may require higher naloxone dose.
Naloxone Hcl Adverse Reactions
Adverse Reactions
Reversal of opioid depression: nausea, vomiting, sweating, tachycardia, increase BP, tremulousness, seizures, ventricular tacychardia and fibrillation, pulmonary edema, cardiac arrest. Also, excessive naloxone doses in post-op: reversal of analgesia, agitation.
Naloxone Hcl Clinical Trials
See Literature
Naloxone Hcl Note
Notes
Formerly known under the brand name Narcan.
Naloxone Hcl Patient Counseling
See Literature
