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Kloxxado Generic Name & Formulations
Legal Class
Rx
General Description
Naloxone HCl 8mg; per spray.
Pharmacological Class
Opioid antagonist.
How Supplied
Single-dose nasal spray—2
Manufacturer
Generic Availability
NO
Kloxxado Indications
Indications
Reversal of known or suspected opioid overdose, including respiratory and/or CNS depression.
Limitations of Use
Not a substitute for emergency medical care.
Kloxxado Dosage and Administration
Adults and Children
Give as single spray intranasally into one nostril. May give additional doses (using a new nasal spray) every 2–3mins in alternate nostrils if unresponsive or relapses into respiratory depression. Seek immediate emergency medical assistance after the first dose.
Kloxxado Contraindications
Not Applicable
Kloxxado Boxed Warnings
Not Applicable
Kloxxado Warnings/Precautions
Warnings/Precautions
Known or suspected opioid dependence; abrupt reversal may precipitate acute withdrawal syndrome. Monitor patients with satisfactory response due to long duration of some narcotics. Post-op use in pre-existing cardiac disease. Have other resuscitative measures available. Elderly. Pregnancy; monitor for neonatal withdrawal symptoms. Nursing mothers.
Kloxxado Pharmacokinetics
See Literature
Kloxxado Interactions
Interactions
Caution with cardiotoxic drugs. Incomplete reversal of buprenorphine or pentazocine; may require higher naloxone dose.
Kloxxado Adverse Reactions
Adverse Reactions
Abdominal pain, asthenia, dizziness, headache, nasal discomfort, presyncope; opioid withdrawal.
Kloxxado Clinical Trials
See Literature
Kloxxado Note
Not Applicable
Kloxxado Patient Counseling
See Literature
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