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Kayexalate Generic Name & Formulations
Legal Class
Rx
General Description
Sodium polystyrene sulfonate; pwd; sodium content 4.1mEq/g.
Pharmacological Class
Cation exchange resin.
How Supplied
Jar (453g)—1
Manufacturer
Kayexalate Indications
Indications
Hyperkalemia.
Limitations of Use
Not for treating life-threatening hyperkalemia due to its delayed onset of action.
Kayexalate Dosage and Administration
Adult
See full labeling. Oral: give in an upright position; 15g as a suspension 1–4 times daily. Rectal enema: 30–50g in 100mL every 6hrs.
Children
See full labeling. 1g per 1mEq of potassium as basis of calculation may be used.
Kayexalate Contraindications
Contraindications
Obstructive bowel disease. Neonates with reduced gut motility.
Kayexalate Boxed Warnings
Not Applicable
Kayexalate Warnings/Precautions
Warnings/Precautions
Avoid in patients at risk for constipation/impaction (eg, history of impaction, chronic constipation, inflammatory bowel disease, ischemic colitis, vascular intestinal atherosclerosis, previous bowel resection, bowel obstruction); discontinue if constipation develops. Post-surgery: avoid if have not had a bowel movement. CHF, hypertension, edema: monitor for fluid overload. Risk of aspiration. Monitor electrolytes (eg, potassium, calcium, magnesium). Neonates: do not give by oral route. Infants.
Kayexalate Pharmacokinetics
See Literature
Kayexalate Interactions
Interactions
Increased risk of intestinal necrosis with concomitant sorbitol; not recommended.
Separate dosing by ≥3hrs before or ≥3hrs after other oral drugs (6hrs in patients with gastroparesis). Increased risk of systemic alkalosis with nonadsorbable cation-donating antacids and laxatives. Reduces absorption of thyroxine, lithium.
Kayexalate Adverse Reactions
Adverse Reactions
Anorexia, constipation, diarrhea, fecal impaction, GI concretions (bezoars), ischemic colitis, nausea, vomiting; intestinal necrosis, electrolyte disturbances.
Kayexalate Clinical Trials
See Literature
Kayexalate Note
Not Applicable
Kayexalate Patient Counseling
See Literature
