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Fomepizole Generic Name & Formulations
Legal Class
Rx
General Description
Fomepizole 1g/mL; soln for IV infusion after dilution; preservative-free.
Pharmacological Class
Alcohol dehydrogenase inhibitor.
How Supplied
Contact supplier
Manufacturer
Fomepizole Indications
Indications
Ethylene glycol or methanol poisoning; or suspected ethylene glycol or methanol ingestion, either alone or in combination with hemodialysis.
Fomepizole Dosage and Administration
Adult
Give by slow IV infusion over 30mins. Loading dose of 15mg/kg, followed by 10mg/kg every 12hrs for 4 doses, then 15mg/kg every 12hrs until ethylene glycol or methanol concentration is <20mg/dL and patient is asymptomatic with normal pH. Hemodialysis: see full labeling.
Children
Not established.
Fomepizole Contraindications
Contraindications
Allergy to pyrazoles.
Fomepizole Boxed Warnings
Not Applicable
Fomepizole Warnings/Precautions
Warnings/Precautions
For dilution/administration: do not use polycarbonate syringes or polycarbonate-containing needles. Renal or hepatic impairment. Renal failure, significant or worsening metabolic acidosis, or high ethylene glycol or methanol concentrations (≥50mg/dL); consider hemodialysis in addition to fomepizole. Obtain blood gases, pH, electrolytes, liver enzymes, BUN, creatinine, urinalysis, ECG, WBCs frequently during therapy. Monitor serum and urine ethylene glycol concentrations and presence of urinary oxalate crystals; or serum methanol concentrations. Monitor for allergic reactions. Elderly. Pregnancy (Cat.C). Nursing mothers.
Fomepizole Pharmacokinetics
See Literature
Fomepizole Interactions
Interactions
Potentiates or potentiated by ethanol. May affect or be affected by CYP450 inducers/inhibitors (eg, phenytoin, carbamazepine, cimetidine, ketoconazole).
Fomepizole Adverse Reactions
Adverse Reactions
Headache, nausea, dizziness, drowsiness, bad taste/metallic taste; rare: mild rash, eosinophilia.
Fomepizole Clinical Trials
See Literature
Fomepizole Note
Not Applicable
Fomepizole Patient Counseling
See Literature
