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Evzio Generic Name & Formulations
Legal Class
Rx
General Description
Naloxone HCl 2mg/0.4mL; soln in a prefilled auto-injector for IM or SC inj; latex-free.
Pharmacological Class
Opioid antagonist.
How Supplied
Prefilled auto-injectors—2 (w. Trainer)
Manufacturer
Evzio Indications
Indications
Emergency treatment of known or suspected opioid overdose, as manifested by respiratory and/or CNS depression.
Evzio Dosage and Administration
Adults and Children
<1yr: Pinch thigh muscle while administering; monitor inj site for residual needle parts and/or infection. ≥1yr: Inject IM or SC into the anterolateral aspect of the thigh (through clothing, if necessary) according to label instructions. All: may give additional doses every 2–3 mins until desired response or emergency medical assistance available. Repeated doses depending on amount, type, and route of administration of the opioid being antagonized may be required.
Evzio Contraindications
Not Applicable
Evzio Boxed Warnings
Not Applicable
Evzio Warnings/Precautions
Warnings/Precautions
Not a substitute for emergency medical care. Monitor patients with satisfactory response due to long duration of some narcotics. Have other resuscitative measures available. Known or suspected opioid dependence; abrupt reversal may precipitate acute withdrawal syndrome. Post-op use in pre-existing cardiac disorders; monitor. Neonates. Elderly. Pregnancy. Nursing mothers.
Evzio Pharmacokinetics
See Literature
Evzio Interactions
Interactions
Caution with cardiotoxic drugs. Incomplete reversal of mixed agonists/antagonists (eg, buprenorphine, pentazocine); may require higher naloxone dose.
Evzio Adverse Reactions
Adverse Reactions
Dizziness, inj site erythema; precipitation of severe opioid withdrawal.
Evzio Clinical Trials
See Literature
Evzio Note
Not Applicable
Evzio Patient Counseling
See Literature
