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Desferal Generic Name & Formulations
Legal Class
Rx
General Description
Deferoxamine mesylate 250mg/mL; for inj after reconstitution.
Pharmacological Class
Iron chelating agent.
How Supplied
Vials 500mg—4
Manufacturer
Desferal Indications
Indications
Acute iron intoxication. Chronic iron overload due to multiple transfusions.
Desferal Dosage and Administration
Adults and Children
Routes other than IM: see literature. <3yrs: not recommended. ≥3yrs: acute iron toxicity: 1g IM initially followed by 500mg every 4 hours for 2 doses; repeat every 4–12 hours if needed; max 6g/day. Chronic iron overload: see literature.
Desferal Contraindications
Contraindications
Severe renal disease. Anuria.
Desferal Boxed Warnings
Not Applicable
Desferal Warnings/Precautions
Warnings/Precautions
Ocular or auditory disturbances. Perform visual acuity tests, slit-lamp exams, funduscopy and audiometry with prolonged therapy. High doses in patients with low ferritin levels may retard growth. Acute respiratory distress syndrome with high IV doses. Flushing, urticaria, hypotension, and shock if given rapid IV. Monitor changes in renal function. Discoloration of urine. Elderly. Pregnancy (Cat.C). Nursing mothers.
Desferal Pharmacokinetics
See Literature
Desferal Interactions
Interactions
Possible impairment of cardiac function with concomitant high dose Vit. C; give max adult dose: 200mg in divided doses. May cause temporary impairment of consciousness with prochlorperazine.
Desferal Adverse Reactions
Adverse Reactions
Localized skin reactions, hypersensitivity, tachycardia, hypotension, shock, dysuria, leg cramps, fever, GI upset; increased serum creatinine, acute renal failure, renal tubular disorder; rare: Yersinia infections, mucormycosis.
Desferal Clinical Trials
See Literature
Desferal Note
Not Applicable
Desferal Patient Counseling
See Literature
