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Calcium Disodium Versenate Generic Name & Formulations
Legal Class
Rx
General Description
Edetate calcium disodium (EDTA) 200mg/mL; IV, IM inj.
Pharmacological Class
Chelating agent.
How Supplied
Amps (5mL)—6
Manufacturer
Calcium Disodium Versenate Indications
Indications
Lead poisoning. Lead encephalopathy.
Calcium Disodium Versenate Dosage and Administration
Adults and Children
See full labeling. Maintain hydration. IM for children and overt lead encephalopathy. Blood lead levels 20–70micrograms/dL: 1g/m2 per day. IV: infuse over 8–12 hours. IM: divided doses every 8–12 hours. Treat for 5 days then stop for 2–4 days; may repeat. If levels over 70micrograms/dL: give with BAL; see full labeling.
Calcium Disodium Versenate Contraindications
Contraindications
Anuria. Renal disease. Hepatitis.
Calcium Disodium Versenate Boxed Warnings
Boxed Warning
Risk of potentially fatal toxic effects (see full labeling).
Calcium Disodium Versenate Warnings/Precautions
Warnings/Precautions
Increased intracranial pressure (IV). Monitor urinalysis, urinary sediment, electrolytes, renal and hepatic function. Discontinue at 1st sign of renal toxicity. Pregnancy (Cat.B). Nursing mothers.
Calcium Disodium Versenate Pharmacokinetics
See Literature
Calcium Disodium Versenate Interactions
Interactions
Steroids may increase renal toxicity. May chelate zinc in insulin preparations.
Calcium Disodium Versenate Adverse Reactions
Adverse Reactions
Acute necrosis of proximal tubules (may result in fatal nephrosis), fever, chills, malaise, hypotension, arrhythmias, zinc deficiency, hypercalcemia, glycosuria, proteinuria, hematuria, large epithelial cells in urinary sediment, GI upset, polydipsia, histamine-like reactions, transient bone marrow depression, anemia, local reactions.
Calcium Disodium Versenate Clinical Trials
See Literature
Calcium Disodium Versenate Note
Not Applicable
Calcium Disodium Versenate Patient Counseling
See Literature
