Bupropion Hcl Extended-release (sr)

See Contraindications. Avoid alcohol. May use with transdermal nicotine (monitor for hypertension). Concomitant levodopa, amantadine may increase CNS toxicity. Caution with drugs that lower seizure threshold (eg, other bupropion products, antipsychotics, antidepressants, theophylline, systemic steroids), or other factors that increase the risk of seizures (eg, cocaine addiction, abuse of CNS stimulants, antidiabetics, anorectics, excessive alcohol, benzodiazepines, sedatives, hypnotics, or opiates). May potentiate CYP2D6 substrates including antidepressants (eg, venlafaxine, nortriptyline, imipramine, desipramine, paroxetine, fluoxetine, sertraline), antipsychotics (eg, haloperidol, risperidone, thioridazine), β-blockers (eg, metoprolol), Class 1C antiarrhythmics (eg, propafenone, flecainide); consider reducing dose of these. May be potentiated by CYP2B6 inhibitors (eg, ticlopidine, clopidogrel); adjust bupropion dose. May be antagonized by CYP2B6 inducers (eg, ritonavir, lopinavir, efavirenz, carbamazepine, phenobarbital, phenytoin); may need to increase bupropion dose. May lower efficacy of drugs metabolized by CYP2D6 (eg, tamoxifen); increase dose of these. May antagonize digoxin; monitor. Smoking cessation may affect theophylline, warfarin, insulin; dose adjustment may be needed. May cause false (+) urine immunoassay screening test for amphetamines.