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Anavip Generic Name & Formulations
Legal Class
Rx
General Description
Crotalidae Immune F(ab’)2 (equine) up to 120mg total protein; per vial; lyophilized pwd for IV infusion after reconstitution and dilution; contains cresol.
Pharmacological Class
Antivenin.
How Supplied
Single-use vial—1
Manufacturer
Generic Availability
NO
Anavip Indications
Indications
Management of patients with North American Pit Viper envenomation.
Anavip Dosage and Administration
Adults and Children
Administer as soon as possible after North American Pit Viper bite at any signs of envenomation. Give by IV infusion over 60mins. First 10mins, proceed slowly at 25–50mL/hr rate; monitor for any allergic reactions. If no reactions occur, increase to 250mL/hr rate until complete. Initially: 10 vials. Observe for ≥60mins after completion of infusion; if no response, repeat additional 10 vial doses every hour until initial control achieved. Once initial control achieved, monitor for ≥18hrs; may give additional 4 vial doses as needed if symptoms re-emerge.
Anavip Contraindications
Not Applicable
Anavip Boxed Warnings
Not Applicable
Anavip Warnings/Precautions
Warnings/Precautions
Risk of anaphylactic reaction (esp. if allergic to horse protein). Discontinue immediately and treat if anaphylaxis or hypersensitivity reactions occur. Monitor for delayed allergic reactions or serum sickness; treat appropriately if necessary. Obtain CBCs, platelets, PT/PTT, serum fibrinogen levels, and routine serum chemistries prior to initiation and periodically thereafter. Risk of transmitting infectious agents (eg, viruses). Allergy to cresol. Pregnancy. Nursing mothers.
Anavip Pharmacokinetics
See Literature
Anavip Interactions
Not Applicable
Anavip Adverse Reactions
Adverse Reactions
Pruritus, nausea, rash, arthralgia, peripheral edema, myalgia, headache, pain in extremity, vomiting, erythema; hypersensitivity reactions, serum sickness.
Anavip Clinical Trials
See Literature
Anavip Note
Not Applicable
Anavip Patient Counseling
See Literature
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