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Rezipres Generic Name & Formulations
Legal Class
Rx
General Description
Ephedrine hydrochloride; 23.5mg/5mL (4.7mg/mL) soln for IV inj (premixed); 47mg/5mL (9.4mg/mL) soln for IV inj (used as provided or after dilution); 47mg/mL soln for IV inj (after dilution).
Pharmacological Class
Sympathomimetic.
How Supplied
Single-dose ampule—1, 10
Manufacturer
Generic Availability
NO
Rezipres Indications
Indications
Clinically important hypotension occurring in the setting of anesthesia.
Rezipres Dosage and Administration
Adult
Give as IV bolus. Initially 4.7–9.4mg, may repeat as needed; max total dose: 47mg.
Children
Not established.
Rezipres Contraindications
Not Applicable
Rezipres Boxed Warnings
Not Applicable
Rezipres Warnings/Precautions
Warnings/Precautions
Tolerance may develop. Repeated doses may cause tachyphylaxis. Have alternative pressor agent readily available. Hypertension. Renal impairment: monitor. Elderly. Newborns. Pregnancy. Nursing mothers.
Rezipres Pharmacokinetics
See Literature
Rezipres Interactions
Interactions
Severe hypertension with concomitant oxytocics (eg, methylergonovine, ergonovine); monitor. Potentiated by MAOIs, clonidine, propofol, atropine; monitor. Antagonized by alpha-blockers, beta-blockers, reserpine, quinidine, mephentermine; monitor. May inhibit hypotensive effect of guanethidine; monitor and adjust dose. May reduce onset time of neuromuscular blockade when used for intubation with rocuronium if used simultaneously. May decrease efficacy of epidural blockade; monitor. Concomitant theophylline may increase frequency of nausea, nervousness, and insomnia; monitor. Concomitant digitalis glycosides may cause cardiac arrhythmias; monitor.
Rezipres Adverse Reactions
Adverse Reactions
Nausea, vomiting, tachycardia, palpitations, reactive hypertension, bradycardia, dizziness, restlessness.
Rezipres Clinical Trials
See Literature
Rezipres Note
Not Applicable
Rezipres Patient Counseling
See Literature
