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Regonol Generic Name & Formulations
Legal Class
Rx
General Description
Pyridostigmine bromide 5mg/mL; soln for IV inj; contains benzyl alcohol.
Pharmacological Class
Cholinesterase inhibitor.
How Supplied
Ampules (2mL)—10
Manufacturer
Regonol Indications
Indications
As a reversal agent or antagonist to the neuromuscular blocking effects of nondepolarizing muscle relaxants.
Regonol Dosage and Administration
Adult
Individualize. Give by IV inj. Usual range: 0.1–0.25mg/kg. Give atropine sulfate or equipotent dose of glycopyrrolate immediately prior to or simultaneously with Regonol.
Children
Not recommended.
Regonol Contraindications
Contraindications
Intestinal or urinary obstruction.
Regonol Boxed Warnings
Not Applicable
Regonol Warnings/Precautions
Warnings/Precautions
Bronchial asthma. Cardiac dysrhythmias. Electrolyte imbalance. Adrenal cortical insufficiency. Renal impairment. Neonates. Pregnancy (Cat.C).
Regonol Pharmacokinetics
See Literature
Regonol Interactions
Interactions
Concomitant 4-aminopyridine may delay onset. Possible resistance to reversal with antibiotics associated with paralysis (eg, aminoglycosides, tetracyclines, bacitracin, polymyxin B, colistin, sodium colistimethate). Recurrent paralysis possible with quinidine. Magnesium salts may enhance neuromuscular blockade and interfere with restoration.
Regonol Adverse Reactions
Adverse Reactions
GI upset, increased salivation and bronchial secretions, miosis and diaphoresis, muscle cramps, fasciculation and weakness, rash.
Regonol Clinical Trials
See Literature
Regonol Note
Not Applicable
Regonol Patient Counseling
See Literature
