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Precedex In Sodium Chloride Generic Name & Formulations
Legal Class
General Description
Pharmacological Class
See Also
How Supplied
Single-dose vials (100mcg/mL)—25 (2mL); Single-dose vials (4mcg/mL)—10 (each 20mL); Single-dose bottles (4mcg/mL)—20 (50mL), 10 (100mL), 1 (250mL)
Manufacturer
Generic Availability
Mechanism of Action
Precedex In Sodium Chloride Indications
Indications
For sedation of initially intubated and mechanically ventilated adult patients during treatment in an intensive care setting. For sedation of non-intubated adult patients prior to and/or during surgical and other procedures. For sedation of non-intubated pediatric patients aged 1 month to <18 years prior to and during non-invasive procedures.
Precedex In Sodium Chloride Dosage and Administration
Adult
Individualize. Give by continuous infusion not to exceed 24hrs. Initiation of ICU sedation: loading infusion of 1mcg/kg over 10mins; patients converting from alternate sedative therapy: a loading dose may not be required; >65yrs, hepatic impairment: reduce dose. Maintenance of ICU sedation: 0.2–0.7mcg/kg/hr; >65yrs, hepatic impairment: reduce dose. Initiation of procedural sedation: loading infusion of 1mcg/kg over 10mins, less invasive procedures: 0.5mcg/kg over 10mins; awake fiberoptic intubation patients: loading infusion of 1mcg/kg over 10mins; >65yrs: loading infusion of 0.5mcg/kg over 10mins; hepatic impairment: reduce dose. Maintenance of procedural sedation: initially 0.6mcg/kg/hr and titrated to achieve desired effect with doses ranging from 0.2–1mcg/kg/hr; awake fiberoptic intubation patients: 0.7mcg/kg/hr until endotracheal tube is secured; >65yrs, hepatic impairment: reduce dose.
Children
Initiation of ICU or other surgical procedural sedation: not established. Initiation of sedation during non-invasive procedures: <1month: not established. Individualize. Give by continuous infusion not to exceed 24hrs. 1month–<2yrs: loading infusion of 1.5mcg/kg over 10mins; 2yrs–<18yrs: loading infusion of 2mcg/kg over 10mins; consider dose reduction if clinically indicated. Maintenance of sedation during non-invasive procedures (1month–<18yrs): initially 1.5mcg/kg/hr and titrated to achieve desired effect with doses ranging from 0.5–1.5mcg/kg/hr; titrate as clinically warranted based on response.
Precedex In Sodium Chloride Contraindications
Not Applicable
Precedex In Sodium Chloride Boxed Warnings
Not Applicable
Precedex In Sodium Chloride Warnings/Precautions
Warnings/Precautions
Should be administered by persons skilled in management of patients in intensive care or operating room setting. Advanced heart block and/or severe ventricular dysfunction. Hypovolemia, diabetes, chronic hypertension, elderly: increased risk of bradycardia and hypotension. Withdrawal symptoms (adults: within 24-48hrs after infusion discontinued; children: after infusions <2hrs). Discontinue if hyperthermia or pyrexia is suspected; monitor. Hepatic impairment. Pregnancy. Nursing mothers: monitor infants.
Precedex In Sodium Chloride Pharmacokinetics
Elimination
Precedex In Sodium Chloride Interactions
Interactions
Precedex In Sodium Chloride Adverse Reactions
Adverse Reactions
Hypotension, bradycardia, dry mouth, bradypnea, hypertension; sinus arrest, transient hypertension (w. loading dose).
Precedex In Sodium Chloride Clinical Trials
See Literature
Precedex In Sodium Chloride Note
Not Applicable
Precedex In Sodium Chloride Patient Counseling
See Literature
