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Pliaglis Generic Name & Formulations
Legal Class
Rx
General Description
Lidocaine 7%, tetracaine 7%; emulsion cream.
Pharmacological Class
Topical anesthetic (amide-type + ester-type).
How Supplied
Cream—30g
Manufacturer
Generic Availability
NO
Pliaglis Indications
Indications
Local analgesia for superficial dermatological procedures (eg, dermal filler injection, pulsed dye laser therapy, facial laser resurfacing, laser-assisted tattoo removal).
Pliaglis Dosage and Administration
Adult
Do not exceed recommended dose or duration. Apply to intact skin prior to procedure; spread evenly and thinly across treatment area using a metal spatula or tongue depressor. Dermal filler inj or facial laser ablation: apply for 20–30mins. Laser-assisted tattoo removal: apply for 60mins. Amount (length) to apply: see full labeling.
Children
Not established.
Pliaglis Contraindications
Contraindications
PABA hypersensitivity.
Pliaglis Boxed Warnings
Not Applicable
Pliaglis Warnings/Precautions
Warnings/Precautions
Risk of methemoglobinemia (esp. in G6PD deficiency, congenital or idiopathic methemoglobinemia, cardiac or pulmonary compromise, infants <6 months of age, concurrent exposure to oxidizing agents or metabolites); monitor. Avoid overexposure. Severe hepatic disease. Pseudocholinesterase deficiency. Risks of secondary exposure to children and pets; may be toxic. Avoid contact with eyes, mucous membranes, or areas with a compromised skin barrier (eg, broken or inflamed). Acutely ill. Debilitated. Elderly. Pregnancy. Nursing mothers.
Pliaglis Pharmacokinetics
See Literature
Pliaglis Interactions
Interactions
Increased risk of methemoglobinemia when concurrently exposed to nitrates/nitrites, local anesthetics, antineoplastic agents, antibiotics, antimalarials, anticonvulsants, others. Toxicity may be potentiated by Class I antiarrhythmics (eg, tocainide, mexiletine); caution. Additive effects with other products containing local anesthetics; consider the amount absorbed from all formulations.
Pliaglis Adverse Reactions
Adverse Reactions
Localized reactions (eg, erythema, skin discoloration, edema), allergic reactions (eg, urticaria, angioedema, bronchospasm, shock).
Pliaglis Clinical Trials
See Literature
Pliaglis Note
Not Applicable
Pliaglis Patient Counseling
See Literature
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