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Pancuronium Bromide Injection Generic Name & Formulations
Legal Class
Rx
General Description
Pancuronium bromide 1mg/mL, 2mg/mL; soln for IV inj; contains benzyl alcohol.
Pharmacological Class
Neuromuscular blocker (nondepolarizing).
How Supplied
Contact supplier.
Manufacturer
Pancuronium Bromide Injection Indications
Indications
Adjunct to general anesthesia to facilitate tracheal intubation, and to provide skeletal muscle relaxation during surgery or mechanical ventilation.
Pancuronium Bromide Injection Dosage and Administration
Adults and Children
Individualize. Adjunct to anesthesia: Initially 0.04 to 0.1mg/kg, then may use incremental doses starting at 0.01mg/kg. Relaxation for intubation: inject bolus dose of 0.06 to 0.1mg/kg. Neonates: give test dose 1st of 0.02mg/kg. Monitor with a peripheral nerve stimulator to avoid overdosage.
Pancuronium Bromide Injection Contraindications
Not Applicable
Pancuronium Bromide Injection Boxed Warnings
Not Applicable
Pancuronium Bromide Injection Warnings/Precautions
Warnings/Precautions
To be administered under the supervision of experienced clinicians. Have intubation, artificial respiration, oxygen therapy and reversal agents available. Myasthenia gravis or myasthenic (Eaton-Lambert) syndrome (do test dose and monitor). Pre-existing pulmonary disease. Renal disease or failure. Hepatic and/or biliary tract disease. Cardiovascular disease and edematous state. Long-term use in I.C.U. Immobilized for long periods. Severe obesity or neuromuscular disease; monitor airway and ventilation. Electrolyte imbalance. Adrenal cortical insufficiency. Neonates. Elderly. Pregnancy (Cat.C). Nursing mothers.
Pancuronium Bromide Injection Pharmacokinetics
See Literature
Pancuronium Bromide Injection Interactions
Interactions
Prior administration of succinylcholine may potentiate effects (delay dose or give pancuronium 1st). Potentiated by volatile inhalational anesthetics (eg, enflurane, isoflurane, halothane), aminoglycosides, tetracyclines, bacitracin, polymyxin B, colistin, sodium colistimethate, magnesium salts. Significant additive effects with pancuronium bromide-metocurine and pancuronium bromide-d-tubocurarine combinations than with the individual drugs given alone. Potential severe ventricular arrhythmias in concomitant with tricyclics and halothane. Caution with quinidine injection.
Pancuronium Bromide Injection Adverse Reactions
Adverse Reactions
Skeletal muscle weakness or prolonged paralysis, circulatory effects, salivation, transient rash; rare: hypersensitivity reactions.
Pancuronium Bromide Injection Clinical Trials
See Literature
Pancuronium Bromide Injection Note
Notes
Formerly known under the brand name Pavulon.
Pancuronium Bromide Injection Patient Counseling
See Literature
