Nimbex

See full labeling. Individualize. IV bolus: Initial dose: 0.15mg/kg or 0.2mg/kg (up to 0.4mg/kg have been used; with neuromuscular disease: max 0.02mg/kg); duration of action with propofol anesthesia: 0.15mg/kg: approx. 55mins, 0.2mg/kg: approx. 61mins. Maintenance: 0.03mg/kg; generally required 40–50mins after initial dose of 0.15mg/kg or 50–60mins after initial dose of 0.2mg/kg. No adjustment in initial maintenance dose necessary when cisatracurium is given shortly after initiation of volatile agents or when used with propofol anesthesia. Continuous infusion: may be given after initial bolus dose to patients with spontaneous recovery during extended surgical procedures or extended need for mechanical ventilation in the ICU. Surgery: infuse at a rate of 3mcg/kg/min initially, then reduce to 1–2mcg/kg/min; titrate based on level of blockade. Under isoflurane/enflurane anesthesia for ≥30mins: reduce rate by 30–40%. CABG: consider reducing rate; see full labeling. ICU: 3mcg/kg/min; titrate based on level of blockade.