Midazolam Hcl Injection

Individualize, titrate slowly. Preoperative sedation/anxiolysis/amnesia: <60yrs: 0.07-0.08mg/kg deep IM inj dosed up to 1 hour before surgery. Sedation/anxiolysis/amnesia for procedures: <60yrs: initially 1–2.5mg IV; administer over 2 minutes, allow additional 2 minutes to evaluate sedation, may increase dose in small increments (max 2.5mg) to total max 5mg in ≥2 minute increments. ≥60yrs or other risk factors: reduce dose and slow inj or infusion rate, see literature. Induction of anesthesia: Administer IV over 20–30 seconds; allow 2 minutes for effect. Unpremedicated: <55yrs: initially 0.3–0.35mg/kg; if needed to complete induction, increments of approx. 25% of initial dose may be used; resistant cases: up to 0.6mg/kg total dose may be used; >55yrs: initially 0.3mg/kg; severe systemic disease, debilitated: initially 0.15–0.25mg/kg. Premedicated: usual range: 0.15–0.35mg/kg: see literature. Continuous IV infusion: loading dose: 0.01–0.05mg/kg; may repeat dose at 10–15 minute intervals until adequate sedation achieved. Maintenance of sedation: initially 0.02–0.1mg/kg/hr; adjust to find minimum effective infusion rate.