LYRICA CR Dosage & Rx Info | Uses, Side Effects

Lyrica Cr Generic Name & Formulations

Legal Class

General Description

Pregabalin 82.5mg, 165mg, 330mg; ext-rel tabs.

Pharmacological Class

Alpha-2 delta ligand.

How Supplied

Caps—90; CR tabs—30; Soln—16oz

Manufacturer

Pfizer Inc.

Mechanism of Action

Pregabalin binds with high affinity to the alpha2-delta site (an auxiliary subunit of voltage-gated calcium channels) in central nervous system tissues. Although the mechanism of action of pregabalin has not been fully elucidated, some results related to pregabalin (such as gabapentin) suggest that binding to the alpha2-delta subunit may be involved in pregabalin's anti-nociceptive and antiseizure effects in animals.

Lyrica Cr Indications

Indications

Neuropathic pain associated with diabetic peripheral neuropathy (DPN). Postherpetic neuralgia (PHN).

Lyrica Cr Dosage and Administration

Adult

Swallow whole. Take once daily after evening meal. DPN: initially 165mg daily, may increase to max 330mg/day within 1 week. PHN: initially 165mg daily, may increase to 330mg daily within 1 week; max 660mg/day if insufficient relief after 2–4wks. Conversion from Lyrica capsules, oral soln: see full labeling. For all: renal impairment (CrCl 30–60mL/min): reduce dose (see full labeling); (CrCl <30mL/min or hemodialysis): dose with Lyrica.

Children

Not established.

Lyrica Cr Contraindications

Not Applicable

Lyrica Cr Boxed Warnings

Not Applicable

Lyrica Cr Warnings/Precautions

Warnings/Precautions

Discontinue if angioedema, hypersensitivity reactions, myopathy or markedly elevated creatine kinase levels occur. Monitor for new or worsening of depression, suicidal thoughts/behavior, and/or unusual changes in mood/behavior. Underlying respiratory depression; monitor and consider initiating at a low dose. CHF (w. NYHA Class III/IV status). Ocular conditions. Diabetes (monitor skin integrity). Avoid abrupt cessation (taper over ≥1 week). Pregnancy. Nursing mothers: not recommended.

Lyrica Cr Pharmacokinetics

Absorption

Bioavailability (Lyrica CR): reduced if taken on an empty stomach. Peak plasma concentrations: ~8–10 hours.

Distribution

Apparent volume of distribution: ~0.5 L/kg.

Elimination

Renal (90%). Half-life: 6.3 hours.

Lyrica Cr Interactions

Interactions

Increased risk for serious respiratory depression when concomitant CNS depressants, opioids. Potentiates CNS depression with alcohol, other CNS depressants. Additive edema, weight gain with thiazolidinediones. Increased risk of angioedema with concomitant ACEIs.

Lyrica Cr Adverse Reactions

Adverse Reactions

Dizziness, somnolence, dry mouth, edema, blurred vision, weight gain, thinking abnormal (primarily difficulty with concentration/attention); elevated creatine kinase, decreased platelets, PR prolongation, male-mediated teratogenicity; may be tumorigenic. Also in children: increased appetite.

Lyrica Cr

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