Forane

— THERAPEUTIC CATEGORIES —
  • Anesthetics
PAGE CONTENTS
  • Jump to Section
  • Generic Name & Formulations
  • Indications
  • Dosage and Administration
  • Contraindications
  • Boxed Warnings
  • Warnings/Precautions
  • Pharmacokinetics
  • Interactions
  • Adverse Reactions
  • Clinical Trials
  • Note
  • Patient Counseling

    • Forane Generic Name & Formulations

    Legal Class

    Rx

    General Description

    Isoflurane; liq for inhalation.

    Pharmacological Class

    Inhalation anesthetic.

    How Supplied

    Bottles (100mL, 250mL)—6

    Manufacturer

    Baxter

    Generic Availability

    YES

    Forane Indications

    Indications

    Induction and maintenance of general anesthesia.

    Forane Dosage and Administration

    Adults and Children

    See full labeling. Individualize. Induction: inspired concentrations of 1.5–3% isoflurane usually produce surgical anesthesia in 7–10 minutes. Maintenance: surgical levels of anesthesia may be sustained with a 1–2.5% concentration when nitrous oxide is used concomitantly. An additional 0.5–1% may be required when isoflurane is given using oxygen alone. If added relaxation is required, supplemental doses of muscle relaxants may be used.

    Forane Contraindications

    Contraindications

    In whom general anesthesia is contraindicated. Hypersensitivity to other halogenated agents. Genetic susceptibility to malignant hyperthermia. History of confirmed hepatitis due to a halogenated inhalational anesthetic or a history of unexplained moderate to severe hepatic dysfunction (eg, jaundice associated with fever and/or eosinophilia) after anesthesia with isoflurane or other halogenated inhalational anesthetics.

    Forane Boxed Warnings

    Not Applicable

    Forane Warnings/Precautions

    Warnings/Precautions

    To be administered only by those experienced in general anesthesia. Have intubation, artificial ventilation, oxygen and circulatory resuscitation available. Monitor for perioperative hyperkalemia esp. in pediatric patients during post-op period and those with latent or overt neuromuscular disease (eg, Duchenne muscular dystrophy); cardiac arrhythmias and death may occur. Risk of malignant hyperthermia; discontinue all triggering agents if suspected (eg, volatile anesthetic agents, succinylcholine). Underlying hepatic conditions. Pediatric neurotoxicity risk with repeated or prolonged use. Pregnancy. Nursing mothers.

    Forane Pharmacokinetics

    See Literature

    Forane Interactions

    Interactions

    Caution with desiccated CO2 absorbents; replace before administration. Caution with drugs known to cause hepatic dysfunction. Hyperkalemia with succinylcholine. Potentiates effects of muscle relaxants, esp. nondepolarizing muscle relaxants. Marked hypotension with calcium antagonists. MAC reduced by concomitant nitrous oxide, opioids (eg, fentanyl). Concomitant beta blockers may exaggerate cardiovascular effects of inhalational anesthetics. Concomitant MAOIs may increase the risk of hemodynamic instability (during surgery, medical procedures).

    Forane Adverse Reactions

    Adverse Reactions

    Agitation, breath holding, chills/shivering, cough, delirium, laryngospasm, nausea, vomiting; respiratory depression, arrhythmias, elevated liver enzymes, hypotension; hepatic reactions (eg, post-op hepatic dysfunction, hepatitis with/without jaundice, hepatic necrosis or failure), hypersensitivity reactions, QTc prolongation.

    Forane Clinical Trials

    See Literature

    Forane Note

    Not Applicable

    Forane Patient Counseling

    See Literature

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