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Emerphed Generic Name & Formulations
Legal Class
Rx
General Description
Ephedrine sulfate 5mg/mL; premixed soln for IV inj.
Pharmacological Class
Sympathomimetic.
How Supplied
Single-dose vials (10mL), single-dose prefilled syringes (5mL, 10mL)—10
Manufacturer
Generic Availability
NO
Mechanism of Action
Ephedrine sulfate acts directly as an agonist at alpha- and beta-adrenergic receptors and indirectly causes the release of norepinephrine from sympathetic neurons. Pressor effects by direct alpha- and beta-adrenergic receptor activation are mediated by increases in arterial pressures, cardiac output, and peripheral resistance. Ephedrine sulfate stimulates heart rate and cardiac output and variably increases peripheral resistance, resulting in increased blood pressure.
Emerphed Indications
Indications
Treatment of clinically important hypotension occurring in the setting of anesthesia.
Emerphed Dosage and Administration
Adult
Do not dilute. Give as IV bolus. Initially 5–10mg, may repeat as needed; max total dose: 50mg.
Children
Not established.
Emerphed Contraindications
Not Applicable
Emerphed Boxed Warnings
Not Applicable
Emerphed Warnings/Precautions
Warnings/Precautions
Tolerance may develop. Repeated doses may cause tachyphylaxis. Have alternative pressor agent readily available. Hypertension. Renal impairment: monitor. Elderly. Pregnancy. Nursing mothers.
Emerphed Pharmacokinetics
Elimination
Renal.
Emerphed Interactions
Interactions
Severe postpartum hypertension with concomitant oxytocics (eg, methylergonovine, ergonovine); monitor. Potentiated by MAOIs, clonidine, propofol, atropine; monitor. Antagonized by alpha-blockers, beta-blockers, reserpine, quinidine, mephentermine; monitor. May inhibit hypotensive effect of guanethidine; monitor and adjust dose. May reduce onset time of neuromuscular blockade when used for intubation with rocuronium if used simultaneously. May decrease efficacy of epidural blockade; monitor. Concomitant theophylline may increase frequency of nausea, nervousness, and insomnia. Concomitant digitalis glycosides may cause cardiac arrhythmias; monitor.
Emerphed Adverse Reactions
Adverse Reactions
Nausea, vomiting, tachycardia, palpitations, reactive hypertension, bradycardia, dizziness, restlessness.
Emerphed Clinical Trials
See Literature
Emerphed Note
Not Applicable
Emerphed Patient Counseling
See Literature
