Diprivan

See full lableing. Individualize. Allow 3–5 mins between dose adjustments. General anesthesia induction (<55yrs): 40mg every 10 seconds until induction onset. Elderly, debilitated, ASA-PS III or IV, cardiac anesthesia, neurosurgery: 20mg every 10 seconds until induction onset. General anesthesia maintenance as infusion (<55yrs and neurosurgery): initially 100–200mcg/kg/min for 10–15 mins, reduce to 50–100mcg/kg/min. Elderly, debilitated, ASA-PS III or IV: 50–100mcg/kg/min. Cardiac anesthesia: As the primary agent: 100–150mcg/kg/min; with primary opioid: 50–100mcg/kg/min. General anesthesia maintenance as intermittent bolus (<55yrs): increments of 20–50mg as needed. Initiation of MAC sedation: give by slow infusion of 100–150mcg/kg/min for 3–5 mins or slow injection of 0.5mg/kg over 3–5 mins followed immediately by maintenance infusion. Maintenance of MAC sedation (<55yrs): infuse 25–75mcg/kg/min (preferred) or give incremental boluses of 10mg or 20mg; elderly, debilitated, ASA-PS III or IV, neurosurgical patients: reduce dose by 20%. ICU sedation: initially infuse 5 mcg/kg/min for at least 5 mins; increase in increments of 5–10mcg/kg/min over 5–10 mins until clinical effect is achieved. Maintenance: 5–50mcg/kg/min or higher; continue until 10–15 mins prior to extubation. May give 10mg or 20mg bolus to rapidly increase depth of sedation in patients not at risk of hypotension.