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Amidate Generic Name & Formulations
Legal Class
Rx
General Description
Etomidate 2mg/mL; soln for IV inj.
Pharmacological Class
Hypnotic.
How Supplied
Vial—10mL, 20mL; Ampul—10mL, 20mL; Abboject syringe—20mL
Manufacturer
Generic Availability
YES
Amidate Indications
Indications
For the induction of general anesthesia. For the supplementation of subpotent anesthetic agents (eg, nitrous oxide in oxygen) during maintenance of anesthesia for short operative procedures (eg, dilation and curettage, cervical conization).
Amidate Dosage and Administration
Adults and Children
<10yrs: not recommended. Induction: Give by IV inj over 30–60 seconds. ≥10yrs: Individualize. Usual range: 0.2–0.6mg/kg. Usual dose: 0.3mg/kg. Elderly: may need to reduce dose. Supplementation: smaller increments may be given.
Amidate Contraindications
Not Applicable
Amidate Boxed Warnings
Not Applicable
Amidate Warnings/Precautions
Warnings/Precautions
To be administered only by those experienced in general anesthesia. May reduce plasma cortisol and aldosterone concentrations; consider exogenous replacement in patients undergoing severe stress. Pediatric neurotoxicity risk with repeated or prolonged use. Renal impairment. Elderly (may induce cardiac depression). Labor & delivery: not recommended. Pregnancy (Cat.C). Nursing mothers.
Amidate Pharmacokinetics
See Literature
Amidate Interactions
Interactions
Concomitant IV fentanyl and other neuroactive drugs; may need to adjust etomidate dose.
Amidate Adverse Reactions
Adverse Reactions
Transient venous pain on inj, transient skeletal muscle movements including myoclonus, hyper- or hypoventilation, apnea, laryngospasm, hiccup, snoring, hyper- or hypotension, tachycardia, arrhythmias, post-op nausea/vomiting.
Amidate Clinical Trials
See Literature
Amidate Note
Not Applicable
Amidate Patient Counseling
See Literature
