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Akovaz Generic Name & Formulations
Legal Class
Rx
General Description
Ephedrine sulfate 50mg/mL (must be diluted); 25mg/5mL (premixed); soln for IV bolus.
Pharmacological Class
Sympathomimetic.
How Supplied
Single-dose vials (50mg/mL)—25; Single-dose prefilled syringes (25mg/5mL)—10
Manufacturer
Generic Availability
YES
Akovaz Indications
Indications
Treatment of clinically important hypotension occurring in the setting of anesthesia.
Akovaz Dosage and Administration
Adult
Give as IV bolus. Initially 5–10mg, may repeat as needed; max total dose: 50mg. Adjust dosage based on blood pressure goal.
Children
Not established.
Akovaz Contraindications
Not Applicable
Akovaz Boxed Warnings
Not Applicable
Akovaz Warnings/Precautions
Warnings/Precautions
Tolerance may develop. Repeated doses may cause tachyphylaxis. Have alternative pressor agent readily available. Hypertension. Renal impairment: monitor. Elderly. Pregnancy. Nursing mothers.
Akovaz Pharmacokinetics
See Literature
Akovaz Interactions
Interactions
Severe postpartum hypertension with concomitant oxytocics (eg, methylergonovine, ergonovine); monitor. Potentiated by MAOIs, clonidine, propofol, atropine; monitor. Antagonized by alpha-blockers, beta-blockers, reserpine, quinidine, mephentermine; monitor. May inhibit hypotensive effect of guanethidine; monitor and adjust dose. May reduce onset time of neuromuscular blockade when used for intubation with rocuronium if used simultaneously. May decrease efficacy of epidural blocker; monitor. Concomitant theophylline may increase frequency of nausea, nervousness, insomnia. Concomitant digitalis glycosides may cause cardiac arrhythmias; monitor.
Akovaz Adverse Reactions
Adverse Reactions
Nausea, vomiting, tachycardia, palpitations, reactive hypertension, bradycardia, ventricular ectopics, dizziness, restlessness.
Akovaz Clinical Trials
See Literature
Akovaz Note
Not Applicable
Akovaz Patient Counseling
See Literature
