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Triamcinolone Acetonide Dental Paste Generic Name & Formulations
Legal Class
Rx
General Description
Triamcinolone acetonide 0.1%; dental paste.
Pharmacological Class
Steroid.
How Supplied
Contact supplier.
Manufacturer
Mechanism of Action
Like other topical corticosteroids, triamcinolone acetonide has anti-inflammatory, antipruritic, and vasoconstrictive properties. The mechanism of the anti-inflammatory activity of the topical steroids, in general, is unclear. However, corticosteroids are thought to act by the induction of phospholipase A2 inhibitory proteins, collectively called lipocortins. It is postulated that these proteins control the biosynthesis of potent mediators of inflammation such as prostaglandins and leukotrienes by inhibiting the release of their common precursor, arachidonic acid. Arachidonic acid is released from membrane phospholipids by phospholipase A2.
Triamcinolone Acetonide Dental Paste Indications
Indications
Adjunct in oral inflammation.
Triamcinolone Acetonide Dental Paste Dosage and Administration
Adult
Press (do not rub) thin film onto lesion at bedtime and, if needed, 2–3 times daily after meals. Reevaluate if no improvement in 7 days.
Children
Not recommended.
Triamcinolone Acetonide Dental Paste Contraindications
Contraindications
Fungal, viral, or bacterial infections of the mouth or throat.
Triamcinolone Acetonide Dental Paste Boxed Warnings
Not Applicable
Triamcinolone Acetonide Dental Paste Warnings/Precautions
Warnings/Precautions
Discontinue if irritation develops and initiate appropriate therapy. Evaluate periodically for evidence of HPA axis suppression if on prolonged therapy; withdraw or reduce frequency of application if occurs. Tuberculosis. Diabetes. Pregnancy: may be teratogenic. Nursing mothers.
Triamcinolone Acetonide Dental Paste Pharmacokinetics
Elimination
Renal.
Triamcinolone Acetonide Dental Paste Interactions
Not Applicable
Triamcinolone Acetonide Dental Paste Adverse Reactions
Adverse Reactions
Local irritation or sensitization (discontinue if occurs); possible systemic effects (eg, adrenal suppression, glucose intolerance, protein catabolism, peptic ulcer activation).
Triamcinolone Acetonide Dental Paste Clinical Trials
See Literature
Triamcinolone Acetonide Dental Paste Note
Not Applicable
Triamcinolone Acetonide Dental Paste Patient Counseling
See Literature
