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Salagen Generic Name & Formulations
Legal Class
Rx
General Description
Pilocarpine (as HCl) 5mg, 7.5mg; tabs.
Pharmacological Class
Cholinergic.
How Supplied
Tabs—100
Manufacturer
Salagen Indications
Indications
Dry mouth (xerostomia) due to radiotherapy for head and neck cancer or Sjogren's syndrome.
Salagen Dosage and Administration
Adult
Cancer: Initially 5mg three times daily; range 15–30mg daily; max 10mg/dose. Sjogren's syndrome: 5mg four times daily. Moderate hepatic impairment for both: 5mg twice daily.
Children
Not recommended.
Salagen Contraindications
Contraindications
Uncontrolled asthma. When miosis is undesirable (iritis, narrow-angle glaucoma).
Salagen Boxed Warnings
Not Applicable
Salagen Warnings/Precautions
Warnings/Precautions
Severe hepatic impairment: not recommended. Cardiovascular disease. Controlled asthma. Chronic bronchitis. COPD. Cholethiasis. Biliary tract disease. Nephrolithiasis. Cognitive or psychiatric disorders. Activities requiring visual acuity. Pregnancy (Cat.C). Nursing mothers: not recommended.
Salagen Pharmacokinetics
See Literature
Salagen Interactions
Interactions
Cardiac conduction disturbances with β-blockers. Potentiates parasympathomimetics. Antagonizes anticholinergics (eg, atropine, ipratropium).
Salagen Adverse Reactions
Adverse Reactions
Sweating, nausea, rhinitis, chills, flushing, urinary frequency, dizziness, asthenia, headache, abnormal vision.
Salagen Clinical Trials
See Literature
Salagen Note
Not Applicable
Salagen Patient Counseling
See Literature
