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Peridex Oral Rinse Generic Name & Formulations
Legal Class
Rx
General Description
Chlorhexidine gluconate 0.12%; contains alcohol 11.6%.
Pharmacological Class
Antimicrobial.
How Supplied
Rinse—4oz, 16oz
Manufacturer
Mechanism of Action
Peridex provides antimicrobial activity during oral rinsing. The clinical significance of its antimicrobial activities is not clear. Microbiological sampling of plaque has shown a general reduction of counts of certain assayed bacteria, both aerobic and anaerobic, ranging from 54–97% through six months use.
Peridex Oral Rinse Indications
Indications
Gingivitis.
Peridex Oral Rinse Dosage and Administration
Adult
≥18yrs: Start after dental prophylaxis. Rinse with 15mL (undiluted) twice daily (AM & PM) for 30 seconds after brushing teeth; expectorate. Do not rinse with water or other mouthwashes, brush teeth, or eat immediately after use.
Children
<18yrs: not recommended.
Peridex Oral Rinse Contraindications
Not Applicable
Peridex Oral Rinse Boxed Warnings
Not Applicable
Peridex Oral Rinse Warnings/Precautions
Warnings/Precautions
Do dental prophylaxis (calculus removal) before starting, then every 6 months. Coexisting gingivitis and periodontitis (effect on periodontitis not known, may cause increased supra- or subgingival calculus). May stain rough surfaces or margins of anterior facial restorations. Pregnancy (Category B). Nursing mothers.
Peridex Oral Rinse Pharmacokinetics
Absorption
-
Mean plasma level of chlorhexidine gluconate reached a peak of 0.206 mcg/g in humans 30 minutes after ingestion.
Elimination
Fecal (~90%).
Peridex Oral Rinse Interactions
Not Applicable
Peridex Oral Rinse Adverse Reactions
Adverse Reactions
Staining of teeth and other oral surfaces, increase in calculus formation, taste alteration, irritation or changes to oral mucosa (eg, stomatitis, dry mouth, ulceration).
Peridex Oral Rinse Clinical Trials
See Literature
Peridex Oral Rinse Note
Not Applicable
Peridex Oral Rinse Patient Counseling
See Literature
