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Kourzeq Generic Name & Formulations
Legal Class
General Description
Pharmacological Class
How Supplied
Tube (5g)—1
Manufacturer
Generic Availability
NO
Mechanism of Action
Like other topical corticosteroids, triamcinolone acetonide has anti-inflammatory, antipruritic, and vasoconstrictive properties. The mechanism of the anti-inflammatory activity of the topical steroids, in general, is unclear. However, corticosteroids are thought to act by the induction of phospholipase A2 inhibitory proteins, collectively called lipocortins. It is postulated that these proteins control the biosynthesis of potent mediators of inflammation such as prostaglandins and leukotrienes by inhibiting the release of their common precursor, arachidonic acid. Arachidonic acid is released from membrane phospholipids by phospholipase A2.
Kourzeq Indications
Indications
For adjunctive treatment and for the temporary relief of symptoms associated with oral inflammatory lesions and ulcerative lesions resulting from trauma.
Kourzeq Dosage and Administration
Adult
Press a small dab (about ¼ inch; do not rub in) onto lesion until a thin film develops. Apply at bedtime and, if needed, 2–3 times daily after meals. Reevaluate if no improvement in 7 days.
Children
Not established.
Kourzeq Contraindications
Contraindications
Fungal, viral, or bacterial infections of the mouth or throat.
Kourzeq Boxed Warnings
Not Applicable
Kourzeq Warnings/Precautions
Warnings/Precautions
Discontinue if irritation develops and initiate appropriate therapy. Evaluate periodically for evidence of HPA axis suppression if on prolonged therapy; withdraw or reduce frequency of application if occurs. Tuberculosis. Diabetes. Pregnancy: may be teratogenic. Nursing mothers.
Kourzeq Pharmacokinetics
Elimination
Renal.
Kourzeq Interactions
Not Applicable
Kourzeq Adverse Reactions
Adverse Reactions
Burning, itching, irritation, dryness, blistering or peeling not present prior to therapy, perioral dermatitis, allergic contact dermatitis, maceration of the oral mucosa, secondary infection, atrophy of the oral mucosa.
Kourzeq Clinical Trials
See Literature
Kourzeq Note
Not Applicable
Kourzeq Patient Counseling
See Literature
