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Evoxac Generic Name & Formulations
Legal Class
Rx
General Description
Cevimeline HCl 30mg; caps.
Pharmacological Class
Cholinergic.
How Supplied
Caps—100
Manufacturer
Mechanism of Action
Cevimeline is a cholinergic agonist which binds to muscarinic receptors. Muscarinic agonists in sufficient dosage can increase secretion of exocrine glands, such as salivary and sweat glands and increase tone of the smooth muscle in the gastrointestinal and urinary tracts.
Evoxac Indications
Indications
Dry mouth associated with Sjogren's syndrome.
Evoxac Dosage and Administration
Adult
30mg three times daily.
Children
Not recommended.
Evoxac Contraindications
Contraindications
Uncontrolled asthma. When miosis is undesirable (eg, acute iritis, narrow-angle glaucoma).
Evoxac Boxed Warnings
Not Applicable
Evoxac Warnings/Precautions
Warnings/Precautions
History of cardiovascular disease. Controlled asthma. Chronic bronchitis. COPD. History of nephrolithiasis or cholelithiasis. CYP2D6 deficiency. Pregnancy (Cat.C). Nursing mothers: not recommended.
Evoxac Pharmacokinetics
Elimination
Renal. Half-life: ~5 hours.
Evoxac Interactions
Interactions
Potentiated by CYP2D6 and CYP3A3/4 inhibitors. Possible conduction disturbances with β-adrenergic antagonists. Additive effects with parasympathomimetics. May interfere with antimuscarinics.
Evoxac Adverse Reactions
Adverse Reactions
Excessive sweating (dehydration may develop; drink extra water), rhinitis, excessive salivation, UTI, cough, arthralgia, fatigue, insomnia, hot flushes, GI upset, visual disturbances (eg, blurring, decreased visual acuity), others.
Evoxac Clinical Trials
See Literature
Evoxac Note
Not Applicable
Evoxac Patient Counseling
See Literature
