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Zylet Generic Name & Formulations
Legal Class
Rx
General Description
Loteprednol etabonate 0.5% + tobramycin 0.3%, oph susp; contains benzalkonium chloride.
Pharmacological Class
Steroid + aminoglycoside.
How Supplied
Susp—5mL, 10mL
Manufacturer
Generic Availability
NO
Zylet Indications
Indications
Ocular inflammation associated with infection or risk thereof.
Zylet Dosage and Administration
Adult
Instill 1–2 drops into the conjunctival sac of affected eye(s) every 4–6hrs; may increase to every 1–2hrs in first 24–48hrs; reduce dose as symptoms improve; max 20mL for first ℞. Reevaluate if no improvement after 2 days.
Children
Not established.
Zylet Contraindications
Contraindications
Ocular fungal, viral, or mycobacterial infections.
Zylet Boxed Warnings
Not Applicable
Zylet Warnings/Precautions
Warnings/Precautions
Corneal or scleral thinning. Glaucoma. Monitor IOP and for secondary infections and for cataracts in prolonged use (>10 days). Monitor blood levels in combined aminoglycoside therapy. Avoid abrupt cessation. Soft contact lenses (remove during therapy). Pregnancy. Nursing mothers.
Zylet Pharmacokinetics
See Literature
Zylet Interactions
Not Applicable
Zylet Adverse Reactions
Adverse Reactions
Secondary ocular infections, injection, superficial punctate keratitis, increased IOP, ocular discomfort (eg, burning, stinging, itching, discharge) visual/lacrimation/eyelid disorder, photophobia, corneal deposits, headache. May mask or exacerbate ocular infections. May delay wound healing and increase bleb formation after cataract surgery. In prolonged use: increased IOP, optic nerve damage, cataract formation, corneal perforation.
Zylet Clinical Trials
See Literature
Zylet Note
Not Applicable
Zylet Patient Counseling
See Literature
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