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Pred-g Generic Name & Formulations
Legal Class
Rx
General Description
Prednisolone acetate 1%, gentamicin (as sulfate) 0.3%; oph. susp; contains benzalkonium chloride.
Pharmacological Class
Steroid + aminoglycoside.
See Also
How Supplied
Susp—5mL, 10mL; Oint—3.5g
Manufacturer
Mechanism of Action
Corticosteroids suppress the inflammatory response to a variety of agents and they probably delay or slow healing. Since corticosteroids may inhibit the body’s defense mechanism against infection, a concomitant antimicrobial drug may be used when this inhibition is considered to be clinically significant in a particular case.
Pred-g Indications
Indications
Ocular inflammation associated with infection.
Pred-g Dosage and Administration
Adult
1 drop 2–4 times daily; max 20mL for initial ℞.
Children
Not established.
Pred-g Contraindications
Contraindications
Fungal, viral or mycobacterial infections.
Pred-g Boxed Warnings
Not Applicable
Pred-g Warnings/Precautions
Warnings/Precautions
Not for uncomplicated removal of foreign body. Corneal or scleral thinning. Glaucoma. Monitor for secondary infections, cataracts, and intraocular pressure in prolonged use. May mask signs of infection. Avoid abrupt cessation. Pregnancy. Nursing mothers: not recommended.
Pred-g Pharmacokinetics
Elimination
Renal. Half-life: 2.1–3.5 hours (prednisolone).
Pred-g Interactions
Not Applicable
Pred-g Adverse Reactions
Adverse Reactions
In prolonged use increased intraocular pressure, cataracts, corneal perforation, optic nerve damage, secondary infections. Ocular discomfort (eg, burning, stinging, hyperemia, pain, discharge, edema, irritation), visual impairment, blurry vision, foreign body sensation in eyes, dysgeusia, punctate keratitis, delayed wound healing, hypersensitivity or allergic skin reactions.
Pred-g Clinical Trials
See Literature
Pred-g Note
Not Applicable
Pred-g Patient Counseling
See Literature
