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Photrexa Generic Name & Formulations
Legal Class
Rx
General Description
Riboflavin 5'-phosphate 0.146%; oph soln.
Pharmacological Class
Photoenhancer.
See Also
How Supplied
Single-use foil pouch—1, 10; Cross-linking Kit—1 (Photrexa + Photrexa Viscous)
Manufacturer
Generic Availability
NO
Photrexa Indications
Indications
For use in corneal collagen cross-linking with the KXL System: to treat progressive keratoconus or corneal ectasia following refractive surgery.
Photrexa Dosage and Administration
Adult
Debride epithelium to approx. 9mm diameter using standard aseptic technique: see full labeling. ≥14yrs: Instill 1 drop (Photrexa Viscous) every 2mins for 30mins; examine eye (under slit lamp) for yellow flare in the anterior chamber. If the yellow flare is not detected, instill 1 drop (Photrexa Viscous) every 2mins for another 2–3 drops and recheck; repeat as necessary. If detected, perform ultrasound pachymetry. If corneal thickness <400microns: instill 2 drops (Photrexa) every 5–10secs until it increases to ≥400microns. For use during eye irradiation, see full labeling.
Children
<14yrs: not established.
Photrexa Contraindications
Not Applicable
Photrexa Boxed Warnings
Not Applicable
Photrexa Warnings/Precautions
Warnings/Precautions
Must use with the KXL System only. Not for injection. Ulcerative keratitis; monitor for resolution of epithelial defects. Advise patients not to rub eyes for first 5 days after procedure. Monitor for severe eye pain or sudden decrease in vision. Pregnancy: not recommended. Nursing mothers.
Photrexa Pharmacokinetics
See Literature
Photrexa Interactions
Not Applicable
Photrexa Adverse Reactions
Adverse Reactions
Corneal opacity (haze), punctate keratitis, corneal striae, corneal epithelium defect, eye pain, reduced visual acuity, blurred vision, dry eye, photophobia.
Photrexa Clinical Trials
See Literature
Photrexa Note
Not Applicable
Photrexa Patient Counseling
See Literature
