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Oxervate Generic Name & Formulations
Legal Class
Rx
General Description
Cenegermin-bkbj 0.002%; oph soln; preservative-free.
Pharmacological Class
Recombinant human nerve growth factor.
How Supplied
Multiple-dose vials—7 (w. Delivery System Kit)
Manufacturer
Generic Availability
NO
Mechanism of Action
Nerve growth factor is an endogenous protein involved in the differentiation and maintenance of neurons, which acts through specific high-affinity (ie, TrkA) and low-affinity (ie, p75NTR) nerve growth factor receptors in the anterior segment of the eye to support corneal innervation and integrity.
Oxervate Indications
Indications
Neurotrophic keratitis.
Oxervate Dosage and Administration
Adults and Children
<2yrs: not established. ≥2yrs: 1 drop in the affected eye(s) 6 times daily (at 2hr intervals) for 8 weeks.
Oxervate Contraindications
Not Applicable
Oxervate Boxed Warnings
Not Applicable
Oxervate Warnings/Precautions
Warnings/Precautions
Contact lenses (remove; may reinsert lenses 15mins after administration). Pregnancy. Nursing mothers.
Oxervate Pharmacokinetics
See Literature
Oxervate Interactions
Interactions
Allow at least 15mins between application of other topical oph agents. Administer Oxervate 15mins prior to using eye ointment, gel or other viscous eye drops.
Oxervate Adverse Reactions
Adverse Reactions
Eye pain, corneal deposits, foreign body sensation, ocular hyperemia, eye inflammation, increased lacrimation.
Oxervate Clinical Trials
See Literature
Oxervate Note
Not Applicable
Oxervate Patient Counseling
See Literature
